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Effects of kidney function, serum albumin and hemoglobin on dementia severity in the oldest old people with newly diagnosed Alzheimer’s disease in a residential aged care facility: a cross-sectional study
- Source :
- BMC Geriatrics, BMC Geriatrics, Vol 20, Iss 1, Pp 1-10 (2020)
- Publication Year :
- 2020
- Publisher :
- BioMed Central, 2020.
-
Abstract
- Background Chronic kidney disease (CKD), low serum albumin, and anemia are known risk factors for cognitive decline in older people. We investigated the association between kidney function and cognitive impairment severity in oldest-old people with a diagnosis of Alzheimer’s disease (AD). Methods A cross-sectional study of patients aged 80 years and older was conducted at a veterans’ home in Taiwan between 2012 and 2016. Their estimated glomerular filtration rate (eGFR) was determined using the Modification of Diet in Renal Diseases (MDRD) equation. Cognitive function was evaluated with the Mini-Mental State Examination (MMSE) and Clinical Dementia Rating (CDR). Results A total of 84 patients (age mean ± SD, 86.6 ± 3.9 years) had MMSE scores of 10.1 ± 6.7, and CDR scores of 1.6 ± 0.7. The average eGFR was 61.7 ± 21.5 mL/min/1.73m2. The mean hemoglobin concentration was 12.7 ± 1.7 g/dl, and the mean albumin concentration was 4.5 ± 4.8 g/dl. Multivariate regression analyses showed that scores of CDR were significantly correlated with eGFR after adjustment for potential confounders. The scores of MMSE were significantly correlated with serum albumin and hemoglobin after adjustment for potential confounders. Conclusions We found dementia severity was significantly associated with kidney function, serum albumin, and hemoglobin in the oldest-old with AD. We recommend that oldest-old people with a diagnosis of AD be evaluated to determine kidney function, as well as nutritional and hematological status. Further study is needed to establish whether prevention of CKD deterioration, and correction of malnutrition and anemia may help to slow cognitive decline in oldest-old people with dementia.
- Subjects :
- Male
medicine.medical_specialty
Anemia
Clinical Dementia Rating
Serum albumin
Oldest-old
Taiwan
Renal function
lcsh:Geriatrics
Kidney Function Tests
Severity of Illness Index
03 medical and health sciences
Hemoglobins
0302 clinical medicine
Alzheimer Disease
Internal medicine
Activities of Daily Living
medicine
Dementia
Humans
030212 general & internal medicine
Cognitive decline
Mini-mental state examination
Serum Albumin
Aged
Aged, 80 and over
Mini–Mental State Examination
biology
medicine.diagnostic_test
business.industry
medicine.disease
lcsh:RC952-954.6
Cross-Sectional Studies
biology.protein
Female
Geriatrics and Gerontology
Glomerular filtration rate
business
Alzheimer’s disease
Clinical dementia rating
030217 neurology & neurosurgery
Kidney disease
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 14712318
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- BMC Geriatrics
- Accession number :
- edsair.doi.dedup.....9f36be9d64e45275cff69d410abcfebe