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Radiosurgery with a Rotating Gamma System: A Very Effective Treatment for Symptomatic Cerebral Cavernomas
- Source :
- Anticancer research. 37(7)
- Publication Year :
- 2017
-
Abstract
- Aim To evaluate the value of radiosurgery with a rotating gamma-system (RGS) for cerebral cavernomas. Patients and methods Seventy-nine patients with symptomatic cerebral cavernomas underwent RGS radiosurgery at the Bach Mai Hospital, Hanoi, Vietnam. Median dose (single fraction) was 20 Gy (range=14-26 Gy). Endpoints included effect on headache, seizures and tumor size. Results Of 60 patients with headache, 17% had complete response, 82% partial response and 2% stable disease (best response). Of 39 patients with seizures, 31% had complete response, 64% partial response and 5% stable disease. Four patients developed recurrent seizures after 1 year. Regarding the size of cavernoma at 15 months, complete response was observed in 6%, partial response in 75%, stable disease in 15%, progression in 1% and pseudo-progression in 3% of patients. Bleeding within 2 years after RGS radiosurgery occurred in only five patients (6%). RGS dose had no significant impact on outcomes. Conclusion RGS radiosurgery provided very high rates of symptom relief in patients with cerebral cavernomas.
- Subjects :
- Adult
Male
Cancer Research
medicine.medical_specialty
Adolescent
medicine.medical_treatment
Radiosurgery
System a
03 medical and health sciences
Young Adult
0302 clinical medicine
Stable Disease
Symptom relief
Seizures
Medicine
Effective treatment
Humans
In patient
030212 general & internal medicine
Child
Aged
High rate
Tumor size
business.industry
Brain Neoplasms
Headache
Dose-Response Relationship, Radiation
General Medicine
Middle Aged
Surgery
Hemangioma, Cavernous
Treatment Outcome
Oncology
030220 oncology & carcinogenesis
Female
business
Subjects
Details
- ISSN :
- 17917530
- Volume :
- 37
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Anticancer research
- Accession number :
- edsair.doi.dedup.....9f29a87389ee8648062749ac09938acf