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Tuning the Solid- and Solution-State Fluorescence of the Iron-Chelator Deferasirox

Authors :
Xi-Le Hu
Adam C. Sedgwick
Daniel N. Mangel
Ying Shang
Axel Steinbrueck
Kai-Cheng Yan
Ling Zhu
Dylan W. Snelson
Sajal Sen
Calvin V. Chau
Gabriel Juarez
Vincent M. Lynch
Xiao-Peng He
Jonathan L. Sessler
Source :
Journal of the American Chemical Society. 144:7382-7390
Publication Year :
2022
Publisher :
American Chemical Society (ACS), 2022.

Abstract

Deferasirox, an FDA-approved iron chelator, has gained increasing attention for use in anticancer and antimicrobial applications. Recent efforts by our group led to the identification of this core as an easy-to-visualize aggregation-induced emission platform, or AIEgen, that provides a therapeutic effect equivalent to deferasirox (

Details

ISSN :
15205126 and 00027863
Volume :
144
Database :
OpenAIRE
Journal :
Journal of the American Chemical Society
Accession number :
edsair.doi.dedup.....9f1eebd4c89678d4eabd3ab9ace40510