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Human disease clinical treatment network for the elderly: analysis of the medicare inpatient length of stay and readmission data
- Source :
- Biometrics. 79:404-416
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Clinical treatment outcomes are the quality and cost targets that healthcare providers aim to improve. Most existing outcome analysis focuses on a single disease or all diseases combined. Motivated by the success of molecular and phenotypic human disease networks (HDNs), this article develops a clinical treatment network that describes the interconnections among diseases in terms of inpatient length of stay (LOS) and readmission. Here one node represents one disease, and two nodes are linked with an edge if their LOS and number of readmissions are conditionally dependent. This is the very first HDN that jointly analyzes multiple clinical treatment outcomes at the pan-disease level. To accommodate the unique data characteristics, we propose a modeling approach based on two-part generalized linear models and estimation based on penalized integrative analysis. Analysis is conducted on the Medicare inpatient data of 100,000 randomly selected subjects for the period of 01/2010-12/2018. The resulted network has 1,008 edges for 106 nodes. We analyze key network properties including connectivity, module/hub, and temporal variation. The findings are biomedically sensible. For example, high connectivity and hub conditions, such as disorders of lipid metabolism and essential hypertension, are identified. There are also findings that are less/not investigated in the literature. Overall, this study can provide additional insight into diseases' properties and their interconnections and assist more efficient disease management and healthcare resources allocation. This article is protected by copyright. All rights reserved.
- Subjects :
- Statistics and Probability
Estimation
medicine.medical_specialty
General Immunology and Microbiology
business.industry
Applied Mathematics
media_common.quotation_subject
Node (networking)
General Medicine
Disease
General Biochemistry, Genetics and Molecular Biology
Human disease
Health care
medicine
Quality (business)
Disease management (health)
General Agricultural and Biological Sciences
Intensive care medicine
business
Clinical treatment
media_common
Subjects
Details
- ISSN :
- 15410420 and 0006341X
- Volume :
- 79
- Database :
- OpenAIRE
- Journal :
- Biometrics
- Accession number :
- edsair.doi.dedup.....9f1636e83851b45f4e2e9836b8862f4c