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Point of care with micro fluidic paper based device integrated with nano zeolite–graphene oxide nanoflakes for electrochemical sensing of ketamine
- Source :
- Biosensors and Bioelectronics. 88:249-257
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- The present study was aimed to develop an ultrasensitive technique for electroanalysis of ketamine; a date rape drug. It involved the fabrication of nano-hybrid based electrochemical micro fluidic paper-based analytical device (EμPADs) for electrochemical sensing of ketamine. A paper chip was developed using zeolites nanoflakes and graphene-oxide nanocrystals (Zeo–GO). EμPAD offers many advantages such as facile approach, economical and potential for commercialization. Nanocrystal modified EμPAD showed wide linear range 0.001–5 nM/mL and a very low detection limit of 0.001 nM/mL. The developed sensor was tested in real time samples like alcoholic and non-alcoholic drinks and found good correlation (99%). The hyphenation of EμPAD integrated with nanocrystalline Zeo–GO for detection of ketamine has immense prospective for field-testing platforms. An extensive development could be made for industrial translation of this fabricated device.
- Subjects :
- Paper
Fabrication
Materials science
Point-of-Care Systems
Biomedical Engineering
Biophysics
Nanotechnology
02 engineering and technology
01 natural sciences
law.invention
Beverages
Limit of Detection
law
Nano
Electrochemistry
Electrodes
Detection limit
Anesthetics, Dissociative
Graphene
010401 analytical chemistry
Oxides
Electrochemical Techniques
Equipment Design
General Medicine
Microfluidic Analytical Techniques
021001 nanoscience & nanotechnology
Chip
Nanocrystalline material
0104 chemical sciences
Nanocrystal
Linear range
Zeolites
Nanoparticles
Graphite
Ketamine
0210 nano-technology
Biotechnology
Subjects
Details
- ISSN :
- 09565663
- Volume :
- 88
- Database :
- OpenAIRE
- Journal :
- Biosensors and Bioelectronics
- Accession number :
- edsair.doi.dedup.....9ef8a7c2c1dbdcf166532c790d5eff26