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Changes in Translational Control after Pro-Apoptotic Stress
- Source :
- International Journal of Molecular Sciences, Vol 14, Iss 1, Pp 177-190 (2012), International Journal of Molecular Sciences
- Publication Year :
- 2012
- Publisher :
- MDPI AG, 2012.
-
Abstract
- In stressed cells, a general decrease in the rate of protein synthesis occurs due to modifications in the activity of translation initiation factors. Compelling data now indicate that these changes also permit a selective post-transcriptional expression of proteins necessary for either cell survival or completion of apoptosis when cells are exposed to severe or prolonged stress. In this review, we summarize the modifications that inhibit the activity of the main canonical translation initiation factors, and the data explaining how certain mRNAs encoding proteins involved in either cell survival or apoptosis can be selectively translated.
- Subjects :
- Cell Survival
4E-BPs
Review
Biology
translation initiation
Catalysis
Inorganic Chemistry
lcsh:Chemistry
Eukaryotic translation
Peptide Initiation Factors
Stress, Physiological
IRES
Eukaryotic initiation factor
Protein biosynthesis
Animals
Humans
Initiation factor
RNA, Messenger
Physical and Theoretical Chemistry
Molecular Biology
lcsh:QH301-705.5
Spectroscopy
eIF2
Organic Chemistry
apoptosis
RNA
General Medicine
Molecular biology
Computer Science Applications
Cell biology
Internal ribosome entry site
lcsh:Biology (General)
lcsh:QD1-999
Apoptosis
eIF4F
Protein Biosynthesis
uORF
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Volume :
- 14
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....9ef3e87c78341a18b090ed7fb19d05f9