Photodynamic Antitumor and Antimicrobial Activities of Free‐Base Tetra(4‐methylthiolphenyl)chlorin and Its Tin(IV) Complex

Authors :: Somila Dingiswayo
Kristen Burgess
Balaji Babu
John Mack
Tebello Nyokong
Source :: ChemPlusChem. 87
Publication Year :: 2022
Publisher :: Wiley, 2022.
Abstract: Meso-tetra(4-methylthiolphenyl)chlorin (3) and its Sn(IV) complex (3-Sn) have been synthesized and characterized. The heavy atom effects of the Sn(IV) ion and sulfur atoms result in relatively high singlet oxygen quantum yield values of 0.40 and 0.48. The photodynamic activities against MCF-7 breast cancer cells were determined through irradiation with a Thorlabs 660 nm LED for 30 min (280 mW.cm

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