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Next generation ultrasound platforms for theranostics
- Source :
- Journal of Colloid and Interface Science. 491:151-160
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Microbubbles are a well-established contrast agent which improves diagnostic ultrasound imaging. During the last decade research has focused on expanding their use to include molecular imaging, targeted therapy and imaging modalities other than ultrasound. However, bioadhesion of targeted microbubbles under physiological flow conditions is still difficult to achieve, the main challenge being connected to the poor stability of lipid microbubbles in the body's circulation system. In this article, we investigate the use of polymeric microbubbles based on a poly (vinyl alcohol) shell as an alternative to lipid microbubbles. In particular, we report on the development of microbubble shell modification, using mild reaction conditions, with the aim of designing a multifunctional platform to enable diagnosis and therapy. Superparamagnetic iron oxide nanoparticles and a near infrared fluorescent probe, indocyanine green, are coupled to the bubbles surface in order to support magnetic resonance and fluorescence imaging. Furthermore, anchoring cyclic arginyl-glycyl-aspartic acid (RGD) peptide, and cyclodextrin molecules, allows targeting and drug loading, respectively. Last but not least, shell topography is provided by atomic force microscopy. These applications and features, together with the high echogenicity of poly (vinyl alcohol) microbubbles, may offer a more stable alternative to lipid microbubbles for the development of a multimodal theranostic platform.
- Subjects :
- Diagnostic Imaging
Fluorescence-lifetime imaging microscopy
Vinyl alcohol
Materials science
Surface Properties
Superparamagnetic iron oxide nanoparticles (SPIONs)
Indocyanine green (ICG)
Atomic Force Microscopy (AFM)
Nanotechnology
02 engineering and technology
Coatings and Films
Microbubbles
Surface conjugation
Contrast agent
Specific targeting
Drug delivery
Cyclodextrins
Biomaterials
03 medical and health sciences
chemistry.chemical_compound
Drug Delivery Systems
0302 clinical medicine
Colloid and Surface Chemistry
Electronic
Ultrasonics
Optical and Magnetic Materials
Particle Size
Electronic, Optical and Magnetic Materials
Surfaces, Coatings and Films
Settore CHIM/02 - Chimica Fisica
Molecular Structure
business.industry
beta-Cyclodextrins
Ultrasound
Echogenicity
021001 nanoscience & nanotechnology
Surfaces
chemistry
Polyvinyl Alcohol
030220 oncology & carcinogenesis
Physiological flow
Molecular imaging
0210 nano-technology
business
Subjects
Details
- ISSN :
- 00219797
- Volume :
- 491
- Database :
- OpenAIRE
- Journal :
- Journal of Colloid and Interface Science
- Accession number :
- edsair.doi.dedup.....9ee3e9361b3d969bca5897c5a051c648