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Physiological Functions of NO-Sensitive Guanylyl Cyclase Isoforms
- Source :
- Current Medicinal Chemistry. 23:2653-2665
- Publication Year :
- 2016
- Publisher :
- Bentham Science Publishers Ltd., 2016.
-
Abstract
- NO-sensitive guanylyl cyclase (NO-GC) acts as the receptor for nitric oxide and by the increase in cGMP executes most of the NO effects in the cardiovascular and neuronal system. Two isoforms of NO-GC exist whose existence has not been paid much attention to probably because they reveal comparable regulatory and catalytic properties and therefore cannot be differentiated in vivo. Analysis of mice in which either one of the isoforms has been genetically deleted unequivocally establishes the coexpression of NO-GC1 and NOGC2 in any tissue tested to date with the exception of platelets. In tissues other than brain and platelets, no particular function could be ascribed to a specific NO-GC isoform so far. In contrast, NO-GC1 and NO-GC2 serve different functions in the central nervous system. With NO-GC1`s presynaptic role and NO-GC2`s postsynaptic action, two NO/cGMP pathways have been shown to exist that enhance the strength of synaptic transmission on either side of the synaptic cleft.
- Subjects :
- Blood Platelets
0301 basic medicine
Gene isoform
endocrine system
Synaptic cleft
Central nervous system
PDZ Domains
Blood Pressure
Neurotransmission
Biology
Nitric Oxide
Synaptic Transmission
Biochemistry
Nitric oxide
03 medical and health sciences
chemistry.chemical_compound
Postsynaptic potential
Drug Discovery
medicine
Animals
Protein Isoforms
Platelet
Receptor
Cyclic GMP
Neurons
Pharmacology
Organic Chemistry
Muscle, Smooth
030104 developmental biology
medicine.anatomical_structure
chemistry
Guanylate Cyclase
Molecular Medicine
Subjects
Details
- ISSN :
- 09298673
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Current Medicinal Chemistry
- Accession number :
- edsair.doi.dedup.....9ede694f8aea4cb59281a3a34c74cac5