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Two Different Extranodal Lymphomas in an HIV+ Patient: A Case Report and Review of the Literature
- Source :
- Case Reports in Hematology, Vol 2019 (2019), Case Reports in Hematology
- Publication Year :
- 2019
- Publisher :
- Hindawi Limited, 2019.
-
Abstract
- Human immune deficiency virus- (HIV-) infected individuals present a higher risk of developing malignancies. Herein, we are presenting an unusual case of an untreated HIV+ patient, who developed two distinct lymphoproliferative disorders in a period of 4 years: a primary cutaneous T-cell lymphoma (PCTCL) and a diffuse large B-cell lymphoma (DLBCL) not otherwise specified (NOS), the latter developed while commencing combined antiretroviral therapy (cART). The two lymphomas also showed peculiar features: PCTCL are rarely described in HIV+ setting and particularly at such a low clinical stage, and the DLBCL showed uncommon cytology, non-GCB phenotype, EBER negativity, and absence of c-MYC translocation, all atypical features in this clinical context. This report not only confirms the increased risk of lymphoma for HIV+ patients and HIV infection being one of the major risk factors for lymphoid disorders but draws the attention on the possible occurrence of unusual features, suggesting that HIV serology should always be investigated in the clinical suspicion of lymphoma.
- Subjects :
- EXPRESSION
0301 basic medicine
Oncology
medicine.medical_specialty
Lymphoproliferative disorders
Case Report
Context (language use)
IMMUNITY
Malignancy
Serology
ACTIVATION
03 medical and health sciences
0302 clinical medicine
immune system diseases
hemic and lymphatic diseases
Internal medicine
Medicine
B-cell lymphoma
MALIGNANCY
RISK
INFECTED PATIENTS
lcsh:RC633-647.5
business.industry
Not Otherwise Specified
B-CELL LYMPHOMA
virus diseases
Cancer
lcsh:Diseases of the blood and blood-forming organs
General Medicine
medicine.disease
GENE
CANCER
Lymphoma
030104 developmental biology
030220 oncology & carcinogenesis
HUMAN-IMMUNODEFICIENCY-VIRUS
business
Subjects
Details
- ISSN :
- 20906579 and 20906560
- Volume :
- 2019
- Database :
- OpenAIRE
- Journal :
- Case Reports in Hematology
- Accession number :
- edsair.doi.dedup.....9ecaad1c58eabcc7f90653caac84c2be
- Full Text :
- https://doi.org/10.1155/2019/8959145