Response to Comment on: Lassenius et al. Bacterial Endotoxin Activity in Human Serum Is Associated With Dyslipidemia, Insulin Resistance, Obesity, and Chronic Inflammation. Diabetes Care 2011;34:1809–1815

We thank Koduru et al. (1) for highlighting their findings regarding the effects of diet composition on endotoxemia and inflammation. Based on their results, it is evident that dietary factors may modulate the state of endotoxemia in humans. We, however, believe that the issue is much more complex. Pathogen-associated microbial compounds may arise from various sources: diet, bacterial infections, and commensal microbiota. Different dietary food products contain various amounts of microbial compounds, the biological activity of which might be modulated by nutrient composition and …