Back to Search
Start Over
Factors associated with health-related quality of life in heart failure in 23 000 patients from 40 countries: results of the G-CHF research programme
- Source :
- Johansson, I, Balasubramanian, K, Bangdiwala, S, Mielniczuk, L, Hage, C, Sharma, S K, Branch, K, Zhu, J, Kragholm, K, Sliwa, K, Alla, F, Yonga, G, Roy, A, Orlandini, A, Grinvalds, A, McCready, T, Pogosova, N, Störk, S, McMurray, J J V, Conen, D, Yusuf, S & The GCHF investigators 2022, ' Factors associated with health-related quality of life in heart failure in 23,000 patients from 40 countries : results of the G-CHF research programme ', European Journal of Heart Failure, vol. 24, no. 9, pp. 1478-1490 . https://doi.org/10.1002/ejhf.2535, European Journal of Heart Failure, European Journal of Heart Failure, Oxford University Press (OUP), 2022, ⟨10.1002/ejhf.2535⟩
- Publication Year :
- 2022
-
Abstract
- Aims: To examine clinical and social correlates of health-related quality of life (HRQL) in patients with heart failure (HF) from high- (HIC), upper middle- (UMIC), lower middle- (LMIC) and low-income (LIC) countries. Methods and results: Between 2017 and 2020, 23 292 patients with HF (32% inpatients, 61% men) from 40 countries were enrolled in the Global Congestive Heart Failure study. HRQL was recorded at baseline using the Kansas City Cardiomyopathy Questionnaire (KCCQ)-12. In a cross-sectional analysis, we compared age- and sex-adjusted mean KCCQ-12 summary scores (SS: 0–100, higher = better) between patients from different country income levels. We used multivariable linear regression examining correlations (estimated coefficients) of KCCQ-12-SS with sociodemographic, comorbidity, treatment and symptom covariates. The adjusted model (37 covariates) was informed by univariable findings, clinical importance and backward selection. Mean age was 63 years and 40% of patients were in New York Heart Association (NYHA) class III–IV. Average HRQL was 55 SD 27. It was 62.5 (95% confidence interval [CI] 62.0–63.1) in HIC, 56.8 (56.1–57.4) in UMIC, 48.6 (48.0–49.3) in LMIC, and 38.5 (37.3–39.7) in LICs (p < 0.0001). Strong correlates (estimated coefficient [95% CI]) of KCCQ-12-SS were NYHA class III versus class I/II (−12.1 [−12.8 to −11.4] and class IV versus class I/II (−16.5 [−17.7 to −15.3]), effort dyspnoea (−9.5 [−10.2 to −8.8]) and living in LIC versus HIC (−5.8 [−7.1 to −4.4]). Symptoms explained most of the KCCQ-12-SS variability (partial R 2 = 0.32 of total adjusted R 2 = 0.51), followed by sociodemographic factors (R 2 = 0.12). Results were consistent in populations across income levels. Conclusion: The most important correlates of HRQL in HF patients relate to HF symptom severity, irrespective of country income level.
- Subjects :
- Quality of life
Heart Failure
Male
Health Status
Global
Heart failure
Comorbidity
Middle Aged
Health status
Cross-Sectional Studies
Surveys and Questionnaires
Quality of Life
Correlates
Humans
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Female
Cardiology and Cardiovascular Medicine
Subjects
Details
- ISSN :
- 18790844 and 13889842
- Volume :
- 24
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- European journal of heart failureReferences
- Accession number :
- edsair.doi.dedup.....9ebd7251f4f2f8a09083a0a1eb5fa991