Back to Search
Start Over
Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders
- Source :
- Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020), Nature Communications, Seidlitz, J, Nadig, A, Liu, S, Bethlehem, R A I, Vértes, P E, Morgan, S E, Váša, F, Romero-Garcia, R, Lalonde, F M, Clasen, L S, Blumenthal, J D, Paquola, C, Bernhardt, B, Wagstyl, K, Polioudakis, D, de la Torre-Ubieta, L, Geschwind, D H, Han, J C, Lee, N R, Murphy, D G, Bullmore, E T & Raznahan, A 2020, ' Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders ', Nature Communications, vol. 11, no. 1, 3358 . https://doi.org/10.1038/s41467-020-17051-5
- Publication Year :
- 2020
- Publisher :
- Nature Publishing Group UK, 2020.
-
Abstract
- Neurodevelopmental disorders have a heritable component and are associated with region specific alterations in brain anatomy. However, it is unclear how genetic risks for neurodevelopmental disorders are translated into spatially patterned brain vulnerabilities. Here, we integrated cortical neuroimaging data from patients with neurodevelopmental disorders caused by genomic copy number variations (CNVs) and gene expression data from healthy subjects. For each of the six investigated disorders, we show that spatial patterns of cortical anatomy changes in youth are correlated with cortical spatial expression of CNV genes in neurotypical adults. By transforming normative bulk-tissue cortical expression data into cell-type expression maps, we link anatomical change maps in each analysed disorder to specific cell classes as well as the CNV-region genes they express. Our findings reveal organizing principles that regulate the mapping of genetic risks onto regional brain changes in neurogenetic disorders. Our findings will enable screening for candidate molecular mechanisms from readily available neuroimaging data.<br />How neurodevelopmental disorder-associated risk genes are translated into spatially patterned brain vulnerabilities is unclear. Here, the authors show that disorder-specific patterns of neuroanatomical changes are aligned to brain expression maps of disease risk genes in healthy subjects.
- Subjects :
- 0301 basic medicine
Male
631/378/2649
General Physics and Astronomy
Brain mapping
Genome
59
Transcriptome
Cohort Studies
0302 clinical medicine
631/378/1689/2608
Copy-number variation
lcsh:Science
Child
Cerebral Cortex
Neurons
Brain Mapping
Multidisciplinary
Developmental disorders
article
Middle Aged
Magnetic Resonance Imaging
Oligodendroglia
Female
Neurotypical
Adult
Adolescent
DNA Copy Number Variations
Science
Neuroimaging
Biology
Molecular neuroscience
General Biochemistry, Genetics and Molecular Biology
38
38/91
631/378/340
03 medical and health sciences
Young Adult
Humans
Genetic Predisposition to Disease
Gene
Spatial Analysis
Genome, Human
Gene Expression Profiling
Cognitive neuroscience
General Chemistry
38/61
Gene expression profiling
030104 developmental biology
Neurodevelopmental Disorders
59/57
lcsh:Q
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020), Nature Communications, Seidlitz, J, Nadig, A, Liu, S, Bethlehem, R A I, Vértes, P E, Morgan, S E, Váša, F, Romero-Garcia, R, Lalonde, F M, Clasen, L S, Blumenthal, J D, Paquola, C, Bernhardt, B, Wagstyl, K, Polioudakis, D, de la Torre-Ubieta, L, Geschwind, D H, Han, J C, Lee, N R, Murphy, D G, Bullmore, E T & Raznahan, A 2020, ' Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders ', Nature Communications, vol. 11, no. 1, 3358 . https://doi.org/10.1038/s41467-020-17051-5
- Accession number :
- edsair.doi.dedup.....9eb8e338df915caabc8a33f6c2a3f989