Use of Reporter Genes in the Generation of Vaccinia Virus-Derived Vectors

Authors :: Sara Baldanta
Susana Guerra
Sally Al Ali
Mercedes Fernández-Escobar
UAM. Departamento de Medicina Preventiva y Salud Pública y Microbiología
Source :: Viruses, Biblos-e Archivo. Repositorio Institucional de la UAM, instname, Viruses, Vol 8, Iss 5, p 134 (2016)
Publication Year :: 2016
Publisher :: MDPI AG, 2016.
Abstract: Vaccinia virus (VACV) is one of the most extensively-studied viruses of the Poxviridae family. It is easy to genetically modify, so it has become a key tool for many applications. In this context, reporter genes facilitate the study of the role of foreign genes introduced into the genome of VACV. In this review, we describe the type of reporter genes that have been used to generate reporter-expressing VACV and the applications of the recombinant viruses obtained. Reporter-expressing VACV are currently employed in basic and immunology research, in the development of vaccines and cancer treatment.<br />This work is supported by Grant FIS2011-00127 and Reference SAF2014-54623-R to SG