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Oral sulfate solution versus low‐volume polyethylene glycol for bowel preparation: Meta‐analysis of randomized controlled trials
- Source :
- Digestive Endoscopy. 34:721-728
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Oral sodium sulfate (OSS) solution and low-volume polyethylene glycol-based solutions are two of the more common low-volume purgatives used as colonoscopy preparations. Data on how these different low-volume solutions compare are mixed. Our aim was to conduct a meta-analysis of randomized controlled trials (RCTs) to compare OSS with low-volume polyethylene glycol solutions (PEG) plus ascorbic acid (PEG + Asc) solution with respect to (i) satisfactory bowel preparation, (ii) excellent bowel preparation, and (iii) tolerability.Studies were identified by searching 10 medical databases for reports published from 1974 until 2019. Only fully published RCTs comparing OSS and low-volume PEG-based products with regard to overall satisfactory bowel preparation were included. Pooling was conducted by both fixed-effects and random effects models; results are presented from the random effects model when heterogeneity was significant.Seven studies (involving 2049 subjects) met the inclusion criteria. There was no difference between OSS and PEG + Asc with respect to adequate bowel preparation (risk ratio [RR] 1.02 [0.99-1.06]; P = 0.16). OSS did result in a higher chance of excellent bowel preparation (RR 1.18 [1.06-1.31]; P = 0.03). OSS was associated with a 30% increased risk of nausea (RR 1.35 [1.03-1.77]; P = 0.03) and more than double the risk of vomiting (RR 2.30 [1.63-2.23]; P 0.05) compared with PEG + Asc. Begg's funnel plot indicated low probability of publication bias.Individuals at low risk of inadequate bowel preparation who use OSS for bowel preparation are more likely to achieve excellent bowel preparation, but are more likely to experience nausea and vomiting than are individuals using low-volume PEG-based solutions.
- Subjects :
- medicine.medical_specialty
Vomiting
Nausea
Colonoscopy
Ascorbic Acid
Gastroenterology
Polyethylene Glycols
law.invention
Randomized controlled trial
law
Internal medicine
PEG ratio
medicine
Humans
Radiology, Nuclear Medicine and imaging
Randomized Controlled Trials as Topic
medicine.diagnostic_test
Cathartics
Sulfates
business.industry
Ascorbic acid
Tolerability
Meta-analysis
medicine.symptom
business
Subjects
Details
- ISSN :
- 14431661 and 09155635
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Digestive Endoscopy
- Accession number :
- edsair.doi.dedup.....9eb34a2155c7c532b144222715d0873b