Back to Search Start Over

Evidence for hydrophobic catalysis of DNA strand exchange

Authors :
Bobo Feng
Fredrik Westerlund
Bengt Nordén
Source :
Chemical Communications. 51:7390-7392
Publication Year :
2015
Publisher :
Royal Society of Chemistry (RSC), 2015.

Abstract

The catalytic role of hydrophobic co-solutes in DNA strand exchange is demonstrated by FRET kinetics. Two mechanisms that contribute to this are base stacking destabilisation and nucleation-promoted DNA strand invasion. We propose that hydrophobic catalysis is involved in the strand-exchange activity of recombination enzymes.

Details

ISSN :
1364548X and 13597345
Volume :
51
Database :
OpenAIRE
Journal :
Chemical Communications
Accession number :
edsair.doi.dedup.....9eacf37770f966dd673d5a98be5c3fb7
Full Text :
https://doi.org/10.1039/c5cc01515d