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HLA class I (-A, -B, -C) and class II (-DR, -DQ) polymorphism in the Mauritanian population
- Source :
- BMC Medical Genetics, Vol 19, Iss 1, Pp 1-10 (2018), BMC Medical Genetics
- Publication Year :
- 2018
- Publisher :
- BMC, 2018.
-
Abstract
- Background HLA antigens have been widely studied for their role in transplantation biology, human diseases and population diversity. The aim of this study was to provide the first profile of HLA class I and class II alleles in the Mauritanian population. Methods HLA typing was carried in 93 healthy Mauritanian blood donors, using single specific primer amplification (PCR-SSP). Results Occurrences of the main HLA class I (-A, -B, -C) and class II (-DR, -DQ) antigens in the general population showed that out of the 17 HLA-A allele groups detected, five main HLA-A allele groups: A*02 (18.42%), A*01 (14.04%), A*23 (14.04%), A*30 (13.16%) and A*29 (12.28%) were the most common identified along other 12 relatively minor allele groups. Twenty three allele groups were observed in the locus B of which B*07 (13.46%) was the most prevalent followed by B*15, B*35, B*08 and B*27 all, with a frequency between 7 to 8%. Three prevalent HLA-C allele groups (C*02: 35.09%, C*07: 20.19% and C*06: 13.6%) were detected. The main HLA class II observed allele groups were: DRB1*13 (27.42%), DRB1*03 (24.73%), DRB1*11 (13.98%), DQB1*03 (36.03%), DQB1*02 (22.06%) and DQB1*05 (18.8%). Except for few haplotype in class I (A*02-B*07: 4.45%, A*02-C02: 10%, A*23-C*02: 8.8%, B*07-C*02: 8.8%, B*15-C*02: 8.8%) and in class II (DRB1*13-DQB1*06: 11.94%, DRB1*03-DQB1*02:11.19% and DRB1*03-DQB1*03: 10.45%), the majority of locus combination were in the range of 2–3%. A single predominant haplotype C*02-DRB1*03 (16.67%) was found. Conclusions These results, in agreement with previous data using different tissues markers, underlined the ethnic heterogeneity of the Mauritanian population.
- Subjects :
- 0301 basic medicine
Male
lcsh:Internal medicine
lcsh:QH426-470
Population
Black People
Pcr-ssp
Locus (genetics)
Human leukocyte antigen
HLA-C Antigens
Biology
Polymorphism, Single Nucleotide
03 medical and health sciences
Antigen
Gene Frequency
Genetics
HLA-DQ beta-Chains
Humans
Allele
education
lcsh:RC31-1245
Genetics (clinical)
Alleles
education.field_of_study
HLA-D Antigens
HLA-A Antigens
Haplotype
Mauritania
Molecular biology
Transplantation
Minor allele frequency
HLA
Phylogeography
lcsh:Genetics
030104 developmental biology
Genetics, Population
Haplotypes
Genetic Loci
HLA-B Antigens
Female
Research Article
HLA-DRB1 Chains
Subjects
Details
- Language :
- English
- ISSN :
- 14712350
- Volume :
- 19
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Medical Genetics
- Accession number :
- edsair.doi.dedup.....9ea62b451e0ff03c5829d91896faadd2