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Dietary Supplementation of Antioxidant Compounds Prevents Light-Induced Retinal Damage in a Rat Model
- Source :
- Biomedicines, Volume 9, Issue 9, Biomedicines, Vol 9, Iss 1177, p 1177 (2021)
- Publication Year :
- 2021
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2021.
-
Abstract
- Light-induced retinal damage (LD) is characterized by the accumulation of reactive oxygen species leading to oxidative stress and photoreceptor cell death. The use of natural antioxidants has emerged as promising approach for the prevention of LD. Among them, lutein and cyanidin-3-glucoside (C3G) have been shown to be particularly effective due to their antioxidant and anti-inflammatory activity. However, less is known about the possible efficacy of combining them in a multicomponent mixture. In a rat model of LD, Western blot analysis, immunohistochemistry and electroretinography were used to demonstrate that lutein and C3G in combination or in a multicomponent mixture can prevent oxidative stress, inflammation, gliotic and apoptotic responses thus protecting photoreceptor cells from death with higher efficacy than each component alone. Combined efficacy on dysfunctional electroretinogram was also demonstrated by ameliorated rod and cone photoreceptor responses. These findings suggest the rationale to formulate multicomponent blends which may optimize the partnering compounds bioactivity and bioavailability.
- Subjects :
- Lutein
Antioxidant
QH301-705.5
phototoxicity
oxidative stress
inflammation
neuroprotection
photoreceptor death
electroretinography
nutraceuticals
medicine.medical_treatment
Medicine (miscellaneous)
Pharmacology
medicine.disease_cause
Neuroprotection
Article
General Biochemistry, Genetics and Molecular Biology
Photoreceptor cell
chemistry.chemical_compound
medicine
Biology (General)
chemistry.chemical_classification
Reactive oxygen species
medicine.diagnostic_test
medicine.anatomical_structure
chemistry
Apoptosis
sense organs
Oxidative stress
Electroretinography
Subjects
Details
- Language :
- English
- ISSN :
- 22279059
- Database :
- OpenAIRE
- Journal :
- Biomedicines
- Accession number :
- edsair.doi.dedup.....9e881dc564dd6ebef3f3ef81e6304ccf
- Full Text :
- https://doi.org/10.3390/biomedicines9091177