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Control of aversion by glycine-gated GluN1/GluN3A NMDA receptors in the adult medial habenula
- Source :
- Science, Science, 2019, 366 (6462), pp.250-254. ⟨10.1126/science.aax1522⟩, Science, American Association for the Advancement of Science, 2019, 366 (6462), pp.250-254. ⟨10.1126/science.aax1522⟩
- Publication Year :
- 2019
-
Abstract
- An inhibitor causes neuronal excitation Glycine is thought to be primarily an inhibitory neurotransmitter. However, it also acts as a coagonist on excitatory N -methyl-D-aspartate (NMDA) receptors. Otsu et al. examined the function of the NMDA receptor subunit combination GluN1/GluN3A in the medial habenula (MHb) of adult mice. This NMDA receptor subunit combination in MHb neurons is activated by glycine released from astrocytes. Activation of GluN1/GluN3A NMDA receptors causes depolarization and increased spiking of MHb neurons. Reducing GluN3A receptor subunit levels in the MHb blocks conditioned place aversion. Science , this issue p. 250
- Subjects :
- Patch-Clamp Techniques
Protein subunit
[SDV]Life Sciences [q-bio]
Emotions
Glycine
Nerve Tissue Proteins
Receptors, N-Methyl-D-Aspartate
Article
Cell Line
03 medical and health sciences
Mice
[SCCO]Cognitive science
0302 clinical medicine
Conditioning, Psychological
Premovement neuronal activity
Animals
Humans
Patch clamp
Receptor
Glycine receptor
030304 developmental biology
Mice, Knockout
Neurons
0303 health sciences
Habenula
Multidisciplinary
Behavior, Animal
Chemistry
[SCCO.NEUR]Cognitive science/Neuroscience
3. Good health
[SDV] Life Sciences [q-bio]
Excitatory postsynaptic potential
NMDA receptor
Calcium
Cues
Neuroscience
Neuroglia
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 00368075 and 10959203
- Database :
- OpenAIRE
- Journal :
- Science
- Accession number :
- edsair.doi.dedup.....9e84330689c78715794916ae66051e05
- Full Text :
- https://doi.org/10.1126/science.aax1522