Back to Search
Start Over
Inside the Endometrial Cell Signaling Subway: Mind the Gap(s)
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 19, Iss 9, p 2477 (2018)
- Publication Year :
- 2018
-
Abstract
- Endometrial cells perceive and respond to their microenvironment forming the basis of endometrial homeostasis. Errors in endometrial cell signaling are responsible for a wide spectrum of endometrial pathologies ranging from infertility to cancer. Intensive research over the years has been decoding the sophisticated molecular means by which endometrial cells communicate to each other and with the embryo. The objective of this review is to provide the scientific community with the first overview of key endometrial cell signaling pathways operating throughout the menstrual cycle. On this basis, a comprehensive and critical assessment of the literature was performed to provide the tools for the authorship of this narrative review summarizing the pivotal components and signaling cascades operating during seven endometrial cell fate “routes”: proliferation, decidualization, implantation, migration, breakdown, regeneration, and angiogenesis. Albeit schematically presented as separate transit routes in a subway network and narrated in a distinct fashion, the majority of the time these routes overlap or occur simultaneously within endometrial cells. This review facilitates identification of novel trajectories of research in endometrial cellular communication and signaling. The meticulous study of endometrial signaling pathways potentiates both the discovery of novel therapeutic targets to tackle disease and vanguard fertility approaches.
- Subjects :
- 0301 basic medicine
Angiogenesis
Review
migration
lcsh:Chemistry
Endometrium
angiogenesis
Homeostasis
implantation
lcsh:QH301-705.5
Spectroscopy
Cell Differentiation
General Medicine
3. Good health
Computer Science Applications
Cellular communication
Intercellular Signaling Peptides and Proteins
Critical assessment
Narrative review
Female
Signal transduction
Signal Transduction
proliferation
Neovascularization, Physiologic
Biology
Catalysis
Inorganic Chemistry
03 medical and health sciences
endometrial cell
decidualization
Humans
Embryo Implantation
Physical and Theoretical Chemistry
Molecular Biology
Menstrual Cycle
Cell Proliferation
breakdown
pathway
Regeneration (biology)
Organic Chemistry
Decidualization
Endometrial cell
030104 developmental biology
Blastocyst
Fertility
lcsh:Biology (General)
lcsh:QD1-999
Gene Expression Regulation
regeneration
Stromal Cells
Neuroscience
Transcription Factors
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 19
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- International journal of molecular sciences
- Accession number :
- edsair.doi.dedup.....9e81ec405ea1d3496d4fb1399a2db37e