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Supplementary Figures from Combined VEGF and PD-L1 Blockade Displays Synergistic Treatment Effects in an Autochthonous Mouse Model of Small Cell Lung Cancer

Authors :
Roland T. Ullrich
H. Christian Reinhardt
Michael von Bergwelt-Baildon
Marco Herling
Michael Hallek
Juergen Wolf
Reinhard Buettner
Margarete Odenthal
Hans A. Schlößer
Kristina Golfmann
Alexandra Florin
Richard Riedel
Sebastian Oberbeck
Ignacija Vlasic
Kerstin Wennhold
Sven Borchmann
Sebastian Klein
Felix Dietlein
Anna Schmitt
Martin Thelen
Philipp Schuldt
Lydia Meder
Publication Year :
2023
Publisher :
American Association for Cancer Research (AACR), 2023.

Abstract

Supplementary data supporting an exhausted T cell phenotype in SCLC upon acquired resistance to PD1/PD-L1 blockade which is regulated by VEGF/VEGFR signaling and in addition, an immunosuppressive role of tumor-associated macrophages in the tumor microenvironment

Details

Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....9e6ebdbe4c2b9b6d834aa5794cc91d33
Full Text :
https://doi.org/10.1158/0008-5472.22411920.v1