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Lung cancer prognostic index: a risk score to predict overall survival after the diagnosis of non-small-cell lung cancer
Lung cancer prognostic index: a risk score to predict overall survival after the diagnosis of non-small-cell lung cancer
- Source :
- British Journal of Cancer
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- Introduction: Non-small-cell lung cancer outcomes are poor but heterogeneous, even within stage groups. To improve prognostic precision we aimed to develop and validate a simple prognostic model using patient and disease variables. Methods: Prospective registry and study data were analysed using Cox proportional hazards regression to derive a prognostic model (hospital 1, n=695), which was subsequently tested (Harrell’s c-statistic for discrimination and Cox–Snell residuals for calibration) in two independent validation cohorts (hospital 2, n=479 and hospital 3, n=284). Results: The derived Lung Cancer Prognostic Index (LCPI) included stage, histology, mutation status, performance status, weight loss, smoking history, respiratory comorbidity, sex, and age. Two-year overall survival rates according to LCPI in the derivation and two validation cohorts, respectively, were 84, 77, and 68% (LCPI 1: score⩽9); 61, 61, and 42% (LCPI 2: score 10–13); 33, 32, and 14% (LCPI 3: score 14–16); 7, 16, and 5% (LCPI 4: score ⩾15). Discrimination (c-statistic) was 0.74 for the derivation cohort, 0.72 and 0.71 for the two validation cohorts. Conclusions: The LCPI contributes additional prognostic information, which may be used to counsel patients, guide trial eligibility or design, or standardise mortality risk for epidemiological analyses.
- Subjects :
- Male
0301 basic medicine
Oncology
Cancer Research
Lung Neoplasms
Epidemiology
Health Status
Respiratory Tract Diseases
Comorbidity
0302 clinical medicine
Risk Factors
Carcinoma, Non-Small-Cell Lung
prognostic model
Anaplastic Lymphoma Kinase
Aged, 80 and over
Framingham Risk Score
Smoking
Age Factors
Middle Aged
Prognosis
ErbB Receptors
Survival Rate
030220 oncology & carcinogenesis
Female
Adult
medicine.medical_specialty
Adenocarcinoma
risk score
survival
Young Adult
03 medical and health sciences
Sex Factors
Internal medicine
Weight Loss
medicine
Humans
Lung cancer
Survival rate
Aged
Neoplasm Staging
Proportional Hazards Models
Performance status
Proportional hazards model
business.industry
Receptor Protein-Tyrosine Kinases
Cancer
medicine.disease
lung cancer
030104 developmental biology
non-small-cell lung cancer
Mutation
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 15321827 and 00070920
- Volume :
- 117
- Database :
- OpenAIRE
- Journal :
- British Journal of Cancer
- Accession number :
- edsair.doi.dedup.....9e6367995f3a1bacb22406ecf021d2d6
- Full Text :
- https://doi.org/10.1038/bjc.2017.232