Back to Search Start Over

A 60-Year-Old Woman with Primary Biliary Cholangitis and Crohn's Ileitis Following the Suspension of Ursodeoxycholic Acid

A 60-Year-Old Woman with Primary Biliary Cholangitis and Crohn's Ileitis Following the Suspension of Ursodeoxycholic Acid

Authors :
Mario Romeo
Marina Cipullo
Giorgia Iadanza
Simone Olivieri
Antonietta Gerarda Gravina
Raffaele Pellegrino
Iacopo Panarese
Marcello Dallio
Alessandro Federico
Romeo, Mario
Cipullo, Marina
Iadanza, Giorgia
Olivieri, Simone
Gravina, Antonietta Gerarda
Pellegrino, Raffaele
Panarese, Iacopo
Dallio, Marcello
Federico, Alessandro
Publication Year :
2022

Abstract

BACKGROUND There is a recognized association between inflammatory bowel disease (IBD) and hepatobiliary autoimmune disease, particularly primary sclerosing cholangitis (PSC). There have been fewer reported cases of IBD and primary biliary cholangitis (PBC), which is treated with ursodeoxycholic acid (UDCA). This report presents the case of a 60-year-old woman with PBC who was diagnosed with Crohn's ileitis after suspension of UDCA treatment. CASE REPORT A 66-year-old female patient with PBC was admitted to our department for irrepressible chronic diarrhea and recurrent abdominal pain. PBC was diagnosed on the basis of serological data: chronic (>6 months) increase in alkaline phosphatase (ALP) associated with positivity for specific anti-nuclear antibodies (sp100 and gp210), without requiring a liver biopsy and a magnetic resonance cholangiopancreatography to rule out PSC. Given the intolerance and non-responsiveness according to the Toronto criteria (ALP

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....9e58c808302ce5413a6dbb9298792a76