Back to Search
Start Over
Mechanisms of the Ase1/PRC1/MAP65 family in central spindle assembly
- Source :
- Biological Reviews. 94:2033-2048
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- During cytokinesis, the organization of the spindle midzone and chromosome segregation is controlled by the central spindle, a microtubule cytoskeleton containing kinesin motors and non-motor microtubule-associated proteins. The anaphase spindle elongation 1/protein regulator of cytokinesis 1/microtubule associated protein 65 (Ase1/PRC1/MAP65) family of microtubule-bundling proteins are key regulators of central spindle assembly, mediating microtubule crosslinking and spindle elongation in the midzone. Ase1/PRC1/MAP65 serves as a complex regulatory platform for the recruitment of other midzone proteins at the spindle midzone. Herein, we summarize recent advances in understanding of the structural domains and molecular kinetics of the Ase1/PRC1/MAP65 family. We summarize the regulatory network involved in post-translational modifications of Ase1/PRC1 by cyclin-dependent kinase 1 (Cdk1), cell division cycle 14 (Cdc14) and Polo-like kinase 1 (Plk1) and also highlight multiple functions of Ase1/PRC1 in central spindle organization, spindle elongation and cytokinesis during cell division.
- Subjects :
- 0106 biological sciences
0303 health sciences
Saccharomyces cerevisiae Proteins
Protein Conformation
Spindle midzone
Cathepsin A
Saccharomyces cerevisiae
macromolecular substances
Biology
010603 evolutionary biology
01 natural sciences
PLK1
General Biochemistry, Genetics and Molecular Biology
Spindle elongation
Cell biology
03 medical and health sciences
Microtubule
M Phase Cell Cycle Checkpoints
PRC1
Central spindle
General Agricultural and Biological Sciences
Microtubule-Associated Proteins
Cytokinesis
030304 developmental biology
Anaphase
Subjects
Details
- ISSN :
- 1469185X and 14647931
- Volume :
- 94
- Database :
- OpenAIRE
- Journal :
- Biological Reviews
- Accession number :
- edsair.doi.dedup.....9e40e9767da073eabad29140c36e1efa