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Molecular genetics of Crohn?s disease
- Source :
- Current Opinion in Genetics & Development. 14:264-270
- Publication Year :
- 2004
- Publisher :
- Elsevier BV, 2004.
-
Abstract
- Progress in the genetics of complex diseases has been slow over the past two decades compared to many simple Mendelian traits. However, rapid advances are now being made in inflammatory bowel disease genetics, leading already to identification of the first gene linked to Crohn's disease susceptibility: NOD2/CARD15. Since its discovery three years ago, there has been replication of the association of NOD2/CARD15 mutations with Crohn's disease in many populations, together with identification of phenotypic correlations. Functional studies promise to increase understanding of the primary pathophysiology involved in Crohn's disease and these discoveries may yet change clinical practice.
- Subjects :
- medicine.medical_specialty
Genetic Linkage
Population
Nod2 Signaling Adaptor Protein
Disease
Biology
Inflammatory bowel disease
Mice
symbols.namesake
Crohn Disease
Gene Frequency
Molecular genetics
NOD2
Genetics
medicine
Animals
Humans
Genetic Predisposition to Disease
education
Molecular Biology
Crohn's disease
education.field_of_study
Intracellular Signaling Peptides and Proteins
Chromosome Mapping
medicine.disease
digestive system diseases
Disease Models, Animal
Genetics, Population
Mendelian inheritance
symbols
Identification (biology)
Developmental Biology
Subjects
Details
- ISSN :
- 0959437X
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Current Opinion in Genetics & Development
- Accession number :
- edsair.doi.dedup.....9e3e76af1467f4f5f3878b5b087313af