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COVID-19 through Adverse Outcome Pathways: Building networks to better understand the disease - 3rd CIAO AOP Design Workshop

Authors :
Clerbaux, Laure-Alix
Amigó, Núria
Amorim, Maria João
Bal-Price, Anna
Batista Leite, Sofia
Beronius, Anna
Bostroem, Ann-Charlotte
Carusi, Annamaria
Coecke, Sandra
Concha, Rachel
Daskalopoulos, Evangelos P
Debernardi, Francesca
Edrosa, Eizleayne
Edwards, Steve W
Filipovska, Julija
Garcia-Reyero, Natàlia
Gavins, Felicity N E
Halappanavar, Sabina
Hargreaves, Alan J
Hogberg, Helena T
Huynh, Mylène T
Jacobson, Daniel
Josephs-Spaulding, Jonathan
Kim, Young Jun
Kong, Hyun Joon
Krebs, Catharine E
Lam, Ann
Landesmann, Brigitte
Layton, Adrienne
Lee, Yong Oh
Macmillan, Donna S
Mantovani, Alberto
Margiotta-Casaluci, Luigi
Martens, Marvin
Masereeuw, Rosalinde
Mayasich, Sally A
Mei, Liang Merlin
Mortensen, Holly
Munoz Pineiro, Amalia
Nymark, Penny
Ohayon, Elan
Ojasi, Joshi
Paini, Alicia
Parissis, Nikolaos
Parvatam, Surat
Pistollato, Francesca
Sachana, Magdalini
Sørli, Jorid Birkelund
Sullivan, Kristie M
Sund, Jukka
Tanabe, Shihori
Tsaioun, Katya
Vinken, Mathieu
Viviani, Laura
Waspe, Jennifer
Willett, Catherine
Wittwehr, Clemens
Afd Pharmacology
Orphan drugs development in The Netherlands: from bench to patient
Pharmacology
Bioinformatica
RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health
Source :
Altex, 39(2). Springer International Publishing AG, Altex-Alternatives To Animal Experimentation, 39(2), 322-335. Elsevier GmbH
Publication Year :
2022

Abstract

ALTEX - Alternatives to Animal Experimentation Copyright © 2022 the author(s). On April 28-29, 2021, 50 scientists from different fields of expertise met for the 3rd online CIAO workshop. The CIAO project “Modelling the Pathogenesis of COVID-19 using the Adverse Outcome Pathway (AOP) framework” aims at building a holistic assembly of the available scientific knowledge on COVID-19 using the AOP framework. An individual AOP depicts the disease progression from the initial contact with the SARS-CoV-2 virus through biological key events (KE) toward an adverse outcome such as respiratory distress, anosmia or multiorgan failure. Assembling the individual AOPs into a network highlights shared KEs as central biological nodes involved in multiple outcomes observed in COVID-19 patients. During the workshop, the KEs and AOPs established so far by the CIAO members were presented and posi­tioned on a timeline of the disease course. Modulating factors influencing the progression and severity of the disease were also addressed as well as factors beyond purely biological phenomena. CIAO relies on an interdisciplinary crowd­sourcing effort, therefore, approaches to expand the CIAO network by widening the crowd and reaching stakeholders were also discussed. To conclude the workshop, it was decided that the AOPs/KEs will be further consolidated, inte­grating virus variants and long COVID when relevant, while an outreach campaign will be launched to broaden the CIAO scientific crowd. The CIAO project is steered by the Joint Research Centre of the European Commission (EC-JRC), the Humane Society International (HSI), and the Physicians Committee for Responsible Medicine (PCRM). For Jorid Birkelund Sørli, the research is supported by FIKA, Focused Research Effort on Chemicals in the Working Environment from the Danish Government. For Daniel Jacobson, this work was supported by the Laboratory Directed Research and Development Program of Oak Ridge National Laboratory, managed by UT-Battelle, LLC for the US Department of Energy (LOIS:10074) and the National Institutes of Health 3RF1AG053303-01S2.

Details

Language :
English
ISSN :
1868596X
Volume :
39
Issue :
2
Database :
OpenAIRE
Journal :
Altex
Accession number :
edsair.doi.dedup.....9e3de4bbb61c3bea48b94796ddde6fbe