Back to Search
Start Over
A dynamically deformable microfilter for selective separation of specific substances in microfluidics
- Source :
- Biomicrofluidics
- Publication Year :
- 2020
- Publisher :
- AIP Publishing, 2020.
-
Abstract
- To study an environmental or biological solution, it is essential to separate its constituents. In this study, a 3D-deformable dynamic microfilter was developed to selectively separate the target substance from a solution. This microfilter is a fine metallic nickel structure fabricated using photolithography and electroplating techniques. It is gold-coated across its entire surface with multiple slits of 10–20 μm in width. Its two-dimensional shape is deformed into a three-dimensional shape when used for fluid separation due to hydrodynamic forces. By adjusting the pressure applied to the microfilter, the size of the gap created by deformation can be changed. To effectively isolate the target substance, the relationship between the solution flow rate and the extent of microfilter deformation was investigated. The filtration experiments demonstrated the microfilter’s ability to isolate the target substance with elastic deformation without undergoing plastic deformation. Additionally, modification of the microfilter surface with nucleic acid aptamers resulted in the selective isolation of the target cell, which further demonstrates the potential application of microfilters in the isolation of specific components of heterogeneous solutions.
- Subjects :
- Fluid Flow and Transfer Processes
Materials science
Hydrodynamic forces
Aptamer
010401 analytical chemistry
Microfluidics
Biomedical Engineering
02 engineering and technology
021001 nanoscience & nanotechnology
Condensed Matter Physics
01 natural sciences
0104 chemical sciences
law.invention
Colloid and Surface Chemistry
law
General Materials Science
Deformation (engineering)
Photolithography
Composite material
0210 nano-technology
Electroplating
Solution flow
Filtration
Regular Articles
Subjects
Details
- ISSN :
- 19321058
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Biomicrofluidics
- Accession number :
- edsair.doi.dedup.....9e3bef546c71142fabcf64950d9e543d