Back to Search
Start Over
Association Between Serum Bilirubin and the Progression of Carotid Atherosclerosis in Type 2 Diabetes
- Source :
- Journal of Lipid and Atherosclerosis, Journal of Lipid and Atherosclerosis, Vol 9, Iss 1, Pp 195-204 (2020)
- Publication Year :
- 2020
- Publisher :
- Korean Society of Lipidology and Atherosclerosis, 2020.
-
Abstract
- Objective: This study investigated whether serum bilirubin levels can predict the progression of carotid atherosclerosis in individuals with type 2 diabetes mellitus (T2DM). Methods: This observational study included 1,381 subjects with T2DM in whom serial measurements of carotid intima-media thickness (CIMT) were made at 1- to 2-year intervals for 6–8 years. The progression of carotid atherosclerosis was defined as newly detected plaque lesions on repeat ultrasonography. After dividing total serum bilirubin levels into tertiles, the association between total serum bilirubin at baseline and plaque progression status was analyzed. Results: Among 1,381 T2DM patients, 599 (43.4%) were categorized as having plaque progression in their carotid arteries. Those with plaque progression were significantly older; showed a higher prevalence of hypertension, abdominal obesity, and chronic kidney disease; and had a longer duration of T2DM, higher levels of total cholesterol (TC), triglycerides, and insulin resistance, and lower total bilirubin concentrations than those with no plaque progression. When total serum bilirubin levels were divided into tertiles, the highest tertile group was younger than the lowest tertile group, with higher levels of TC and high-density lipoprotein cholesterol. Multiple logistic regression analysis demonstrated that higher serum bilirubin levels were associated with a significantly lower risk of CIMT progression (odds ratio, 0.584; 95% confidence interval, 0.392–0.870; p=0.008). Age (p
- Subjects :
- medicine.medical_specialty
diabetes mellitus type 2
lcsh:Internal medicine
lcsh:Diseases of the circulatory (Cardiovascular) system
Bilirubin
Endocrinology, Diabetes and Metabolism
Type 2 diabetes
Lower risk
Gastroenterology
chemistry.chemical_compound
Insulin resistance
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Carotid intima-media thickness
lcsh:RC31-1245
Abdominal obesity
business.industry
Diabetes mellitus, type 2
Odds ratio
medicine.disease
Atherosclerosis
chemistry
lcsh:RC666-701
Original Article
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Kidney disease
Subjects
Details
- Language :
- English
- ISSN :
- 22882561 and 22872892
- Volume :
- 9
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of Lipid and Atherosclerosis
- Accession number :
- edsair.doi.dedup.....9e342d7021141b35798c40027f6f7646