Back to Search
Start Over
Functional conservation of interactions between a homeodomain cofactor and a mammalian FTZ-F1 homologue
- Source :
- EMBO reports. 5(6)
- Publication Year :
- 2003
-
Abstract
- Nuclear receptors are master regulators of metazoan gene expression with crucial roles during development and in adult physiology. Fushi tarazu factor 1 (FTZ-F1) subfamily members are ancient orphan receptors with homologues from Drosophila to human that regulate diverse gene expression programs important for developmental processes, reproduction and cholesterol homeostasis in an apparently ligand-independent manner. Thus, developmental and tissue-specific cofactors may be particularly important in modulating the transcriptional activities of FTZ-F1 receptors. In Drosophila, the homeodomain protein Fushi tarazu acts as a cofactor for FTZ-F1 (NR5A3), leading to the hypothesis that a similar type of homeodomain cofactor–nuclear receptor relationship might exist in vertebrates. In this study, we have identified and characterized the homeodomain protein Prox1 as a co-repressor for liver receptor homologue 1 (LRH1/NR5A2), a master regulator of cholesterol homeostasis in mammals. Our study suggests that interactions between LRH1 and Prox1 may fulfil roles both during development of the enterohepatic system and in adult physiology of the liver.
- Subjects :
- Steroidogenic factor 1
Subfamily
Scientific Report
Down-Regulation
Receptors, Cytoplasmic and Nuclear
Biology
Steroidogenic Factor 1
Biochemistry
Histone Deacetylases
Cell Line
Protein Interaction Mapping
Genetics
Animals
Humans
Tissue Distribution
RNA, Messenger
Receptor
Molecular Biology
Transcription factor
Homeodomain Proteins
Liver receptor homolog-1
Tumor Suppressor Proteins
fungi
NKX-homeodomain factor
Protein Structure, Tertiary
DNA-Binding Proteins
Nuclear receptor
Liver
Homeobox
Transcription Factors
Subjects
Details
- ISSN :
- 1469221X
- Volume :
- 5
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- EMBO reports
- Accession number :
- edsair.doi.dedup.....9e01ff3e99344edfb7c6ec5f1b369f19