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Controlled Drug Delivery Systems for Oral Cancer Treatment—Current Status and Future Perspectives
- Source :
- Pharmaceutics, Vol 11, Iss 7, p 302 (2019), Pharmaceutics
- Publication Year :
- 2019
- Publisher :
- MDPI AG, 2019.
-
Abstract
- Oral squamous cell carcinoma (OSCC), which encompasses the oral cavity-derived malignancies, is a devastating disease causing substantial morbidity and mortality in both men and women. It is the most common subtype of the head and neck squamous cell carcinoma (HNSCC), which is ranked the sixth most common malignancy worldwide. Despite promising advancements in the conventional therapeutic approaches currently available for patients with oral cancer, many drawbacks are still to be addressed; surgical resection leads to permanent disfigurement, altered sense of self and debilitating physiological consequences, while chemo- and radio-therapies result in significant toxicities, all affecting patient wellbeing and quality of life. Thus, the development of novel therapeutic approaches or modifications of current strategies is paramount to improve individual health outcomes and survival, while early tumour detection remains a priority and significant challenge. In recent years, drug delivery systems and chronotherapy have been developed as alternative methods aiming to enhance the benefits of the current anticancer therapies, while minimizing their undesirable toxic effects on the healthy non-cancerous cells. Targeted drug delivery systems have the potential to increase drug bioavailability and bio-distribution at the site of the primary tumour. This review confers current knowledge on the diverse drug delivery methods, potential carriers (e.g., polymeric, inorganic, and combinational nanoparticles; nanolipids; hydrogels; exosomes) and anticancer targeted approaches for oral squamous cell carcinoma treatment, with an emphasis on their clinical relevance in the era of precision medicine, circadian chronobiology and patient-centred health care.
- Subjects :
- Oncology
medicine.medical_specialty
medicine.medical_treatment
precision medicine
Pharmaceutical Science
lcsh:RS1-441
Disease
Review
lcsh:Pharmacy and materia medica
03 medical and health sciences
drug delivery systems
0302 clinical medicine
Quality of life (healthcare)
Internal medicine
circadian clock
medicine
030304 developmental biology
0303 health sciences
chronotherapy
business.industry
Cancer
Precision medicine
medicine.disease
Head and neck squamous-cell carcinoma
controlled drug delivery
Chronotherapy (treatment scheduling)
targeted therapies
3. Good health
stomatognathic diseases
Targeted drug delivery
030220 oncology & carcinogenesis
Drug delivery
nanoparticles
business
oral, head and neck squamous cell carcinoma
Subjects
Details
- Language :
- English
- ISSN :
- 19994923
- Volume :
- 11
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Pharmaceutics
- Accession number :
- edsair.doi.dedup.....9df139c241b055ce19d710b644fb80cd