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Evaluation of a continuous combined low-dose regimen of estrogen-progestin for treatment of the menopausal patient
- Source :
- American journal of obstetrics and gynecology. 162(6)
- Publication Year :
- 1990
-
Abstract
- Menopause constitutes a sizable proportion of the adult woman's life, and it is reasonable to consider that most women will benefit from hormone-replacement therapy. Also, it is important to realize that cardiovascular disease is a major cause of morbidity and death in the menopausal patient. Two regimens of hormone-replacement therapy were evaluated in postmenopausal women with 0.625 mg of conjugated equine estrogen with either 2.5 or 5 mg of medroxyprogesterone acetate taken continuously for 52 weeks in 92 patients. The data demonstrated an improvement in menopausal symptoms, a beneficial effect in lipoprotein profiles, the establishment of an atrophic endometrium, and a marked decrease in vaginal bleeding after 13 weeks and a further decrease after 26 weeks. Ideally this regimen will offer better patient compliance and, if the favorable lipoprotein profiles offer protection to the cardiovascular system, the overall health of the American woman will be markedly affected.
- Subjects :
- medicine.medical_specialty
Medroxyprogesterone
medicine.drug_class
Lipoproteins
Urology
Disease
General Biochemistry, Genetics and Molecular Biology
Internal medicine
medicine
Medroxyprogesterone acetate
Humans
Vaginal bleeding
Triglycerides
Gynecology
business.industry
Low dose
Estrogen Replacement Therapy
Obstetrics and Gynecology
Estrogens
General Medicine
Middle Aged
medicine.disease
Menopause
Regimen
Cholesterol
Estrogen
Patient Compliance
Drug Therapy, Combination
Female
Uterine Hemorrhage
medicine.symptom
business
Progestin
Lipoprotein
medicine.drug
Subjects
Details
- ISSN :
- 00029378
- Volume :
- 162
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- American journal of obstetrics and gynecology
- Accession number :
- edsair.doi.dedup.....9deb2ba5b689a0650dd9fca9695cd046