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The Degree of Hyperglycemia Excursion in Patients of Kidney Transplantation (KT) or Liver Transplantation (LT) Assessed by Continuous Glucose Monitoring (CGM): Pilot Study
- Source :
- Journal of Diabetes Research, Vol 2019 (2019), Journal of Diabetes Research
- Publication Year :
- 2019
- Publisher :
- Hindawi Limited, 2019.
-
Abstract
- Objective. This study used a continuous glucose monitoring system (CGMS) to investigate the glucose profiles and assess the degree of hyperglycemic excursion after kidney or liver transplantation during the early period after operation. Methods. Patients to whom a CGMS was attached during a postoperative period of approximately one month after transplantation were included. The CGM data of 31 patients including 24 with kidney transplantation (KT) and seven with liver transplantation (LT) were analyzed. Results. Hyperglycemia over 126 mg/dL (fasting) or 200 g/dL (postprandial) occurred in 42.1% (8/19) and 16.7% (1/6) of KT and LT patients, respectively, during this early period after transplantation, except for patients with preexisting diabetes (5 KT, 1 LT). The average mean amplitude of glycemic excursion (MAGE) and mean absolute glucose (MAG) levels were 91.18±26.51 vs. 65.66±22.55 (P<0.05) and 24.62±7.78 vs. 18.18±7.07 (P<0.05) in KT vs. LT patients, respectively, in patients without preexisting DM or PTDM patients who showed normal glucose levels. Average increase from the lowest level to the peak glucose value was higher in KT patients than LT patients (P<0.05). Conclusions. The transplanted organ also needs to be considered as an important factor affecting glucose control and the occurrence of more severe glucose excursions in patients who receive transplantation although immunosuppression agents are well-known important factors; however, our study was limited to the early posttransplantation period. Further studies involving CGM follow-up at regular intervals based on the time since transplantation are needed.
- Subjects :
- Adult
Blood Glucose
Male
medicine.medical_specialty
Time Factors
Article Subject
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Pilot Projects
Liver transplantation
Gastroenterology
Severity of Illness Index
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Endocrinology
Predictive Value of Tests
Risk Factors
Internal medicine
Diabetes mellitus
Medicine
Humans
Kidney transplantation
Glycemic
Retrospective Studies
lcsh:RC648-665
business.industry
Blood Glucose Self-Monitoring
Reproducibility of Results
Immunosuppression
Middle Aged
medicine.disease
Kidney Transplantation
Liver Transplantation
Transplantation
Postprandial
Treatment Outcome
Predictive value of tests
Hyperglycemia
Female
business
Biomarkers
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 23146753 and 23146745
- Volume :
- 2019
- Database :
- OpenAIRE
- Journal :
- Journal of Diabetes Research
- Accession number :
- edsair.doi.dedup.....9de82f4c3302741cbbff61a4159cad83