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The Acute and Early Effects of Whole-Brain Irradiation on Glial Activation, Brain Metabolism, and Behavior
- Source :
- Molecular Imaging and Biology, 22(4), 1012-1020. SPRINGER, Molecular Imaging and Biology
- Publication Year :
- 2020
- Publisher :
- SPRINGER, 2020.
-
Abstract
- Purpose Radiotherapy is a frequently applied treatment modality for brain tumors. Concomitant irradiation of normal brain tissue can induce various physiological responses. The aim of this study was to investigate whether acute and early-delayed effects of brain irradiation on glial activation and brain metabolism can be detected with positron emission tomography (PET) and whether these effects are correlated with behavioral changes. Procedures Rats underwent 0-, 10-, or 25-Gy whole-brain irradiation. At 3 and 31 days post irradiation, 1-(2-chlorophenyl)-N-[11C]methyl-(1-methylpropyl)-3-isoquinoline carboxamide ([11C]PK11195) and 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) PET scans were acquired to detect changes in glial activation (neuroinflammation) and glucose metabolism, respectively. The open-field test (OFT) was performed on days 6 and 27 to assess behavioral changes. Results Twenty-five-gray-irradiated rats showed higher [11C]PK11195 uptake in most brain regions than controls on day 3 (striatum, hypothalamus, accumbens, septum p p 11C]PK11195 uptake than controls and 10-Gy-irradiated group (p 11C]PK11195 uptake in individual brain regions of 25-Gy treated rats remained stable or slightly increased between days 3 and 31. In contrast, a significant reduction (p 18F]FDG uptake on day 3 (p 18F]FDG uptake decreased between days 3 and 31 in all groups; no significant differences between groups were observed anymore on day 31, except for increased uptake in the hypothalamus in the 10-Gy group. The OFT did not show any significant differences between groups. Conclusions Non-invasive PET imaging indicated that brain irradiation induces neuroinflammation and a metabolic flare, without causing acute or early-delayed behavioral changes.
- Subjects :
- Male
Cancer Research
Cerebellum
Brain irradiation
PET imaging
Striatum
Somatosensory system
0302 clinical medicine
RAT MODEL
Carbon Radioisotopes
IN-VIVO
Microglia activation
medicine.diagnostic_test
Behavior, Animal
LONG-TERM SURVIVORS
Brain
CRANIAL IRRADIATION
medicine.anatomical_structure
Oncology
Hypothalamus
Positron emission tomography
030220 oncology & carcinogenesis
CEREBRAL GLUCOSE-METABOLISM
Neuroglia
Motor cortex
Research Article
medicine.medical_specialty
Brain imaging
NEUROINFLAMMATION
Brain metabolism
MICROGLIA
03 medical and health sciences
Fluorodeoxyglucose F18
Internal medicine
medicine
Animals
Radiology, Nuclear Medicine and imaging
Rats, Wistar
Neuroinflammation
Behavior
business.industry
TRANSPLANTATION
Body Weight
Isoquinolines
COGNITIVE IMPAIRMENT
Transplantation
Endocrinology
Positron-Emission Tomography
RADIATION
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 15361632
- Volume :
- 22
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Molecular Imaging and Biology
- Accession number :
- edsair.doi.dedup.....9dd29dfc493b82e5cebbce8555816cc5