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The Association between 25-Hydroxyvitamin D Concentration and Disability Trajectories in Very Old Adults: The Newcastle 85+ Study
- Source :
- Nutrients, Vol 12, Iss 2742, p 2742 (2020), Nutrients, Volume 12, Issue 9
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Background: Low vitamin D status is common in very old adults which may have adverse consequences for muscle function, a major predictor of disability. Aims: To explore the association between 25-hydroxyvitamin D [25(OH)D] concentrations and disability trajectories in very old adults and to determine whether there is an &lsquo<br />adequate&rsquo<br />25(OH)D concentration which might protect against a faster disability trajectory. Methodology: A total of 775 participants from the Newcastle 85+ Study for who 25(OH)D concentration at baseline was available. Serum 25(OH)D concentrations of &lt<br />25 nmol/L, 25&ndash<br />50 nmol/L and &gt<br />50 nmol/L were used as cut-offs to define low, moderate and high vitamin D status, respectively. Disability was defined as difficulty in performing 17 activities of daily living, at baseline, after 18, 36 and 60 months. Results: A three-trajectory model was derived (low-to-mild, mild-to-moderate and moderate-to-severe). In partially adjusted models, participants with 25(OH)D concentrations &lt<br />25 nmol/L were more likely to have moderate and severe disability trajectories, even after adjusting for sex, living in an institution, season, cognitive status, BMI and vitamin D supplement use. However, this association disappeared after further adjustment for physical activity. Conclusions: Vitamin D status does not appear to influence the trajectories of disability in very old adults.
- Subjects :
- Male
Pediatrics
medicine.medical_specialty
Activities of daily living
Physical activity
Nutritional Status
030209 endocrinology & metabolism
lcsh:TX341-641
Article
03 medical and health sciences
Disability Evaluation
0302 clinical medicine
Activities of Daily Living
medicine
Vitamin D and neurology
Cognitive status
Humans
030212 general & internal medicine
Vitamin D
Association (psychology)
Severe disability
Geriatric Assessment
Aged, 80 and over
Nutrition and Dietetics
business.industry
Vitamin D Deficiency
vitamin D status
disability
Vitamin D supplement
Female
business
lcsh:Nutrition. Foods and food supply
Food Science
very old adults
Subjects
Details
- Language :
- English
- ISSN :
- 20726643
- Volume :
- 12
- Issue :
- 2742
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....9dcd0b2435dbc7922e38db4539e9c860