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Comparison of clinicopathological characteristics between T-cell prolymphocytic leukemia and peripheral T-cell lymphoma, not otherwise specified
- Source :
- European Journal of Haematology. 98:459-466
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Objectives T-cell prolymphocytic leukemia (T-PLL) is a very rare, aggressive T-cell neoplasm. Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is also a highly aggressive lymphoma. These two diseases can often be confused with each other; therefore, we aimed to determine the clinical and pathological differences between T-PLL and PTCL-NOS. Methods We analyzed 15 T-PLL and 91 PTCL-NOS patients and also compared clinical features between T-PLL and PTCL-NOS with leukemic presentation. Peripheral blood images and biopsy specimens were analyzed, and treatment responses were determined via imaging modalities. The clinicopathological characteristics were statistically compared. Results T-PLL cells were smaller in size than those of PTCL-NOS with leukemic presentation (P=.0068); moreover, PTCL-NOS cells with leukemic presentation were smaller than those of PTCL-NOS without leukemic presentation (P=.0017). Immunophenotypic patterns in T-PLL and PTCL-NOS were similar. Five-year overall survival rates of T-PLL and all PTCL-NOS patients were 57.5% and 36.8%, respectively. No significant differences were found in clinical manifestations or prognoses; T-PLL and PTCL-NOS with leukemic presentation had essentially equivalent characteristics. Conclusion T-PLL and PTCL-NOS may share common biological and clinical characteristics in Japanese patients.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Adolescent
Biopsy
Receptors, Antigen, T-Cell
Peripheral T-cell lymphoma not otherwise specified
Aggressive lymphoma
Immunophenotyping
Diagnosis, Differential
Leukocyte Count
Young Adult
03 medical and health sciences
0302 clinical medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Neoplasm
Neoplasm Metastasis
Child
Prolymphocytic leukemia
Aged
Neoplasm Staging
Aged, 80 and over
Gene Rearrangement
medicine.diagnostic_test
business.industry
Not Otherwise Specified
Lymphoma, T-Cell, Peripheral
Hematology
General Medicine
Middle Aged
Prognosis
medicine.disease
Lymphoma
Treatment Outcome
030220 oncology & carcinogenesis
Leukemia, Prolymphocytic, T-Cell
T-cell prolymphocytic leukemia
Female
business
Biomarkers
030215 immunology
Subjects
Details
- ISSN :
- 09024441
- Volume :
- 98
- Database :
- OpenAIRE
- Journal :
- European Journal of Haematology
- Accession number :
- edsair.doi.dedup.....9dc7e3ce8a1d400fc8bde4c00c9393ca