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Hormonal changes in major depressive disorder
- Source :
- The Keio Journal of Medicine. 38:40-52
- Publication Year :
- 1989
- Publisher :
- Keio Journal of Medicine, 1989.
-
Abstract
- The dexamethasone suppression test (DST) was performed in 38 patients satisfying the Research Diagnostic Criteria (RDC) for cortisol, human growth hormone (hGH), prolactin, triiodothyronine (T3), thyroxine (T4) and thyroid-stimulating hormone (TSH) were determined at 4:00 p.m. before the administration of dexamethasone, whereas cortisol, hGH and TSH were determined at 4:00 p.m. the day after. Among hormonal variables, only cortisol index (the ratio of the pre-DST cortisol to the post-DST cortisol) was barely useful for discriminating depression. The cortisol index was also correlated with RDC incapacitating subcategory and with symptoms of affect such as depressed mood and psychic anxiety.
- Subjects :
- Adult
Male
endocrine system
medicine.medical_specialty
Cortisol awakening response
Adolescent
Hydrocortisone
Dexamethasone
Pituitary Hormones, Anterior
Internal medicine
medicine
Humans
Aged
Depressive Disorder
Triiodothyronine
General Medicine
Middle Aged
medicine.disease
Prolactin
Thyroxine
Endocrinology
Dexamethasone suppression test
Major depressive disorder
Anxiety
Female
medicine.symptom
Psychology
hormones, hormone substitutes, and hormone antagonists
Hormone
medicine.drug
Subjects
Details
- ISSN :
- 18801293 and 00229717
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- The Keio Journal of Medicine
- Accession number :
- edsair.doi.dedup.....9dc0763214142658d9fcef674fa13083
- Full Text :
- https://doi.org/10.2302/kjm.38.40