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Highly versatile SPION encapsulated PLGA nanoparticles as photothermal ablators of cancer cells and as multimodal imaging agents
- Publication Year :
- 2017
- Publisher :
- United Kingdom : Royal Society of Chemistry, 2017.
-
Abstract
- We have designed versatile polymeric nanoparticles with cancer cell specific targeting capabilities via aptamer conjugation after the successful encapsulation of curcumin and superparamagnetic iron oxide nanoparticles (SPIONs) inside a PLGA nanocapsule. These targeted nanocomposites were selectively taken up by tumor cells, under in vitro conditions, demonstrating the effectiveness of the aptamer targeting mechanism. Moreover, the nanocomposite potentially functioned as efficient multiprobes for optical, magnetic resonance imaging (MRI) and photoacoustic imaging contrast agents in the field of cancer diagnostics. The hyperthermic ability of these nanocomposites was mediated by SPIONs upon NIR-laser irradiation. In vitro cytotoxicity was shown by curcumin-loaded nanoparticles as well as the photothermal ablation of cancer cells mediated by the drug-encapsulated nanocomposite demonstrated the potential therapeutic effect of the nanocomposite. In short, we portray the aptamer-conjugated nanocomposite as a multimodal material capable of serving as a contrast agent for MR, photoacoustic and optical imaging. Furthermore, the nanocomposite functions as a targetable drug nanocarrier and a NIR-laser inducible hyperthermic material that is capable of ablating PANC-1 and MIA PaCa-2 cancer cell lines. Refereed/Peer-reviewed
- Subjects :
- Materials science
Aptamer
Biomedical Engineering
Contrast Media
Nanoparticle
Nanotechnology
multimodal imaging
02 engineering and technology
010402 general chemistry
Multimodal Imaging
01 natural sciences
ablation
Nanocomposites
Photoacoustic Techniques
chemistry.chemical_compound
Drug Delivery Systems
Polylactic Acid-Polyglycolic Acid Copolymer
Cell Line, Tumor
Neoplasms
Humans
General Materials Science
Lactic Acid
Magnetite Nanoparticles
Drug Carriers
Nanocomposite
Optical Imaging
Aptamers, Nucleotide
Photothermal therapy
021001 nanoscience & nanotechnology
Magnetic Resonance Imaging
0104 chemical sciences
PLGA
chemistry
Cancer cell
Curcumin
cancer cells
nanoparticles
Nanocarriers
0210 nano-technology
Polyglycolic Acid
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....9dc02b46272f9ee8746d9bd41b2ac3ec