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A multifunctional metal–organic framework based tumor targeting drug delivery system for cancer therapy
- Source :
- Nanoscale. 7:16061-16070
- Publication Year :
- 2015
- Publisher :
- Royal Society of Chemistry (RSC), 2015.
-
Abstract
- Drug delivery systems (DDSs) with biocompatibility and precise drug delivery are eagerly needed to overcome the paradox in chemotherapy that high drug doses are required to compensate for the poor biodistribution of drugs with frequent dose-related side effects. In this work, we reported a metal-organic framework (MOF) based tumor targeting DDS developed by a one-pot, and organic solvent-free "green" post-synthetic surface modification procedure, starting from the nanoscale MOF MIL-101. Owing to the multifunctional surface coating, premature drug release from this DDS was prevented. Due to the pH responsive benzoic imine bond and the redox responsive disulfide bond at the modified surface, this DDS exhibited tumor acid environment enhanced cellular uptake and intracellular reducing environment triggered drug release. In vitro and in vivo results showed that DOX loaded into this DDS exhibited effective cancer cell inhibition with much reduced side effects.
- Subjects :
- Biodistribution
Materials science
Biocompatibility
Antineoplastic Agents
Pharmacology
Surface coating
Drug Delivery Systems
Targeted drug delivery
In vivo
COS Cells
Chlorocebus aethiops
Drug delivery
Cancer cell
Animals
Humans
Nanoparticles
Surface modification
Tissue Distribution
General Materials Science
HeLa Cells
Subjects
Details
- ISSN :
- 20403372 and 20403364
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Nanoscale
- Accession number :
- edsair.doi.dedup.....9da919179ad34f978c4d932e1f5eb527