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Cognitive phenotypes in Alzheimer's disease and genetic variants in ACE and IDE
- Source :
- Neurobiology of Aging. 33:1486.e1-1486.e2
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- Alzheimer's disease (AD) is generally considered to be a disorder primarily affecting memory. It is increasingly recognized that the clinical presentation or "cognitive phenotype" is variable. The apolipoprotein E ε4 (APOE ε4) allele has been associated with an amnestic presentation, but does not appear to fully explain the high prevalence of family history within this group. We examined polymorphisms in the genes ACE and IDE in relation to cognitive phenotype. In this study 276 participants with AD were categorized into 1 of 4 cognitive phenotype classifications: typical, amnestic, language, and posterior. Family history and possession of the APOE ε4 allele were most prevalent in the amnestic group. Of the 10 genetic variants of IDE, and the 3 genetic variants of ACE studied, only ACErs4291 and ACErs1800764 were nominally associated with the amnestic presentation.
- Subjects :
- Male
Apolipoprotein E
Aging
Disease
Peptidyl-Dipeptidase A
Insulysin
Alzheimer Disease
Insulin-degrading enzyme
Humans
Genetic Predisposition to Disease
Allele
Family history
Genetics
biology
General Neuroscience
Genetic Variation
Angiotensin-converting enzyme
Cognition
Phenotype
biology.protein
Female
Neurology (clinical)
Geriatrics and Gerontology
Cognition Disorders
Psychology
Developmental Biology
Subjects
Details
- ISSN :
- 01974580
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Neurobiology of Aging
- Accession number :
- edsair.doi.dedup.....9d9dbfd85f600d198bdee9c3a58cc731