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Cloning of the IL-1β3 gene and IL-1β4 pseudogene in salmonids uncovers a second type of IL-1β gene in teleost fish
- Source :
- Developmental & Comparative Immunology. 38:431-446
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- To date two closely related interleukin-1β genes (IL-1β1 and IL-β2) have been found in salmonids. The cloning of trout and salmon IL-1β3, and a salmon IL-1β4 pseudogene reveals that two types of IL-1β genes exist in teleost species. Type I teleost IL-1β genes, including salmonid IL-1β3, share a similar 6 coding exon structure as in tetrapods. Type II teleost IL-1β genes, e.g. salmonid IL-1β1-2, lack one or two coding exons at their 5'-end, and share higher identities within this subgroup than within the type I subgroup. Both types of IL-1β genes have been found in species of Salmoniformes, Perciformes and Beloniformes, suggesting the divergence occurred early in teleost evolution. Trout IL-1β3 is highly expressed in ovary suggesting a role in reproduction. A relatively high constitutive expression in gills, spleen and kidney and the up-regulation by PAMPs, proinflammatory cytokines and viral infection suggests IL-1β3 also has a role in inflammation and host defence.
- Subjects :
- Gills
endocrine system
animal structures
Trout
Sequence analysis
Pseudogene
Interleukin-1beta
Molecular Sequence Data
Immunology
Gene Expression
Biology
Kidney
Cell Line
Novirhabdovirus
Fish Diseases
Exon
Salmon
Rhabdoviridae Infections
Animals
Amino Acid Sequence
Cloning, Molecular
Gene
Inflammation
Genetics
Cloning
Beloniformes
Base Sequence
Macrophages
Ovary
Kidney metabolism
Sequence Analysis, DNA
biology.organism_classification
Female
Sequence Alignment
Pseudogenes
Spleen
Developmental Biology
Subjects
Details
- ISSN :
- 0145305X
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Developmental & Comparative Immunology
- Accession number :
- edsair.doi.dedup.....9d9785a2432d8804b4dbafb24ad8040a