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REVISED PREDICTIVE BIOMARKER FOR OCRIPLASMIN THERAPY IN VITREOMACULAR TRACTION DISORDERS

REVISED PREDICTIVE BIOMARKER FOR OCRIPLASMIN THERAPY IN VITREOMACULAR TRACTION DISORDERS

Authors :
Sami Al-Nawaiseh
Peter Szurman
Dalia Al-Rimawi
Boris V. Stanzel
Anna-Maria Seuthe
Annekatrin Rickmann
Source :
Retina. 41:2549-2555
Publication Year :
2021
Publisher :
Ovid Technologies (Wolters Kluwer Health), 2021.

Abstract

Purpose To determine a statistically optimal limit of adhesion size in vitreomacular traction (VMT) syndrome for ocriplasmin treatment. Methods In this retrospective, consecutive, interventional study, we included 106 patients treated with ocriplasmin injection due to VMT between July 2013 and January 2018. A univariate and multivariate risk analysis was performed with grouped factors and continuous factors. We used a receiver operating characteristic curve to measure the prognostic relevance of each continuous factor for therapy success and determined the statistically optimal cutoff value at which specificity and sensitivity are simultaneously maximized. Results Among the grouped factors, only a phakic lens status showed a highly significant positive influence on the resolution of the VMT. For the continuous factors, only the adhesion diameter before injection was a good predictor of anatomical success. The statistically optimal threshold value for the adhesion size was calculated to be 480 µm. Eyes below this limit had a 6.84-fold better chance of VMT resolution compared to eyes with a larger adhesion diameter. Conclusion The threshold value of the VMT diameter for ocriplasmin therapy could be statistically defined as 480 µm and may thus be a new quantitative biomarker to predict treatment success.

Details

ISSN :
0275004X
Volume :
41
Database :
OpenAIRE
Journal :
Retina
Accession number :
edsair.doi.dedup.....9d96f2a408bf66b52f9184a4d069695e
Full Text :
https://doi.org/10.1097/iae.0000000000003244