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REVISED PREDICTIVE BIOMARKER FOR OCRIPLASMIN THERAPY IN VITREOMACULAR TRACTION DISORDERS
REVISED PREDICTIVE BIOMARKER FOR OCRIPLASMIN THERAPY IN VITREOMACULAR TRACTION DISORDERS
- Source :
- Retina. 41:2549-2555
- Publication Year :
- 2021
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2021.
-
Abstract
- Purpose To determine a statistically optimal limit of adhesion size in vitreomacular traction (VMT) syndrome for ocriplasmin treatment. Methods In this retrospective, consecutive, interventional study, we included 106 patients treated with ocriplasmin injection due to VMT between July 2013 and January 2018. A univariate and multivariate risk analysis was performed with grouped factors and continuous factors. We used a receiver operating characteristic curve to measure the prognostic relevance of each continuous factor for therapy success and determined the statistically optimal cutoff value at which specificity and sensitivity are simultaneously maximized. Results Among the grouped factors, only a phakic lens status showed a highly significant positive influence on the resolution of the VMT. For the continuous factors, only the adhesion diameter before injection was a good predictor of anatomical success. The statistically optimal threshold value for the adhesion size was calculated to be 480 µm. Eyes below this limit had a 6.84-fold better chance of VMT resolution compared to eyes with a larger adhesion diameter. Conclusion The threshold value of the VMT diameter for ocriplasmin therapy could be statistically defined as 480 µm and may thus be a new quantitative biomarker to predict treatment success.
- Subjects :
- Male
medicine.medical_specialty
Optimal cutoff
Visual Acuity
Tissue Adhesions
Vitreomacular traction
chemistry.chemical_compound
Fibrinolytic Agents
Retinal Diseases
Vitrectomy
Ophthalmology
Humans
Medicine
Fibrinolysin
Aged
Retrospective Studies
Predictive biomarker
Receiver operating characteristic
business.industry
Ocriplasmin
Univariate
Lens Status
General Medicine
Middle Aged
Peptide Fragments
Vitreous Body
ROC Curve
chemistry
Biomarker (medicine)
Female
business
Biomarkers
Subjects
Details
- ISSN :
- 0275004X
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Retina
- Accession number :
- edsair.doi.dedup.....9d96f2a408bf66b52f9184a4d069695e
- Full Text :
- https://doi.org/10.1097/iae.0000000000003244