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Galacto-oligosaccharides supplementation in prefrail older and healthy adults increased faecal bifidobacteria, but did not impact immune function and oxidative stress
- Source :
- Clinical Nutrition 40 (2021) 5, Clinical Nutrition, 40(5), 3019-3031, Clinical Nutrition, 40(5), 3019-3031. Churchill Livingstone
- Publication Year :
- 2021
-
Abstract
- Background & aims: Ageing is associated with an increased risk of frailty, intestinal microbiota perturbations, immunosenescence and oxidative stress. Prebiotics such as galacto-oligosaccharides (GOS) may ameliorate these ageing-related alterations. We aimed to compare the faecal microbiota composition, metabolite production, immune and oxidative stress markers in prefrail elderly and younger adults, and investigate the effects of GOS supplementation in both groups. Methods: In a randomised controlled cross-over study, 20 prefrail elderly and 24 healthy adults received 21.6 g/day BiotisTM GOS (containing 15.0 g/day GOS) or placebo. Faecal 16S rRNA gene-based microbiota and short-chain fatty acids were analysed at 0,1 and 4 weeks of intervention.Volatile organic compounds were analysed in breath, and stimulated cytokine production, CRP, malondialdehyde, trolox equivalent antioxidant capacity (TEAC) and uric acid (UA) in blood at 0 and 4 weeks. Results: Principle coordinate analysis showed differences in microbial composition between elderly and adults (P
- Subjects :
- Male
0301 basic medicine
Oligosaccharides
Physiology
Gut flora
Critical Care and Intensive Care Medicine
medicine.disease_cause
DISEASE
Feces
chemistry.chemical_compound
0302 clinical medicine
Microbiologie
MALONDIALDEHYDE
Aged, 80 and over
Cross-Over Studies
Nutrition and Dietetics
biology
PLASMA
Probiotics/prebiotics
GUT MICROBIOTA
Age Factors
Immunosenescence
Middle Aged
Malondialdehyde
BREATH
Female
SENSITIVITY
Adult
Immunology
Trolox equivalent antioxidant capacity
030209 endocrinology & metabolism
VOLATILE ORGANIC-COMPOUNDS
Microbiology
Young Adult
03 medical and health sciences
AGE
INFLAMMATION
medicine
Humans
MolEco
Microbiome
FRAILTY
Aged
VLAG
Nutrition
WIMEK
030109 nutrition & dietetics
business.industry
Probiotics
Immunity
Galactose
biology.organism_classification
Oxidative Stress
chemistry
Ageing
Dietary Supplements
PRJEB32547
Uric acid
Bifidobacterium
business
prebiotics
Oxidative stress
Subjects
Details
- Language :
- English
- ISSN :
- 02615614
- Volume :
- 40
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Clinical Nutrition
- Accession number :
- edsair.doi.dedup.....9d95dc64a58421e6169578b4e1581208