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Cardiac fibrosis: new insights into the pathogenesis
- Source :
- International Journal of Biological Sciences
- Publication Year :
- 2018
- Publisher :
- Ivyspring International Publisher, 2018.
-
Abstract
- Cardiac fibrosis is defined as the imbalance of extracellular matrix (ECM) production and degradation, thus contributing to cardiac dysfunction in many cardiac pathophysiologic conditions. This review discusses specific markers and origin of cardiac fibroblasts (CFs), and the underlying mechanism involved in the development of cardiac fibrosis. Currently, there are no CFs-specific molecular markers. Most studies use co-labelling with panels of antibodies that can recognize CFs. Origin of fibroblasts is heterogeneous. After fibrotic stimuli, the levels of myocardial pro-fibrotic growth factors and cytokines are increased. These pro-fibrotic growth factors and cytokines bind to its receptors and then trigger the activation of signaling pathway and transcriptional factors via Smad-dependent or Smad independent-manners. These fibrosis-related transcriptional factors regulate gene expression that are involved in the fibrosis to amplify the fibrotic response. Understanding the mechanisms responsible for initiation, progression, and amplification of cardiac fibrosis are of great clinical significance to find drugs that can prevent the progression of cardiac fibrosis.
- Subjects :
- 0301 basic medicine
TGF-β
Cardiac fibrosis
SMAD
Review
Cardiac fibroblast
Applied Microbiology and Biotechnology
Pathogenesis
Extracellular matrix
03 medical and health sciences
Fibrosis
Transforming Growth Factor beta
medicine
Animals
Humans
Receptor
Molecular Biology
Transcription factor
Ecology, Evolution, Behavior and Systematics
Smad
business.industry
Myocardium
Cell Biology
Fibroblasts
medicine.disease
030104 developmental biology
Cancer research
Signal transduction
business
Developmental Biology
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 14492288
- Volume :
- 14
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- International Journal of Biological Sciences
- Accession number :
- edsair.doi.dedup.....9d8bd87307dd6714d2a9040e654ac9c3