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Wnt/β-catenin signaling links embryonic lung development and asthmatic airway remodeling
- Source :
- Biochimica et biophysica acta. Molecular basis of disease. 1863(12)
- Publication Year :
- 2017
-
Abstract
- Embryonic lung development requires reciprocal endodermal-mesodermal interactions; mediated by various signaling proteins. Wnt/β-catenin is a signaling protein that exhibits the pivotal role in lung development, injury and repair while aberrant expression of Wnt/β-catenin signaling leads to asthmatic airway remodeling: characterized by hyperplasia and hypertrophy of airway smooth muscle cells, alveolar and vascular damage goblet cells metaplasia, and deposition of extracellular matrix; resulting in decreased lung compliance and increased airway resistance. The substantial evidence suggests that Wnt/β-catenin signaling links embryonic lung development and asthmatic airway remodeling. Here, we summarized the recent advances related to the mechanistic role of Wnt/β-catenin signaling in lung development, consequences of aberrant expression or deletion of Wnt/β-catenin signaling in expansion and progression of asthmatic airway remodeling, and linking early-impaired pulmonary development and airway remodeling later in life. Finally, we emphasized all possible recent potential therapeutic significance and future prospectives, that are adaptable for therapeutic intervention to treat asthmatic airway remodeling.
- Subjects :
- 0301 basic medicine
Embryonic Development
WIF1
Biology
03 medical and health sciences
0302 clinical medicine
Airway resistance
medicine
Animals
Humans
Molecular Biology
Lung
Wnt Signaling Pathway
Wnt signaling pathway
respiratory system
Embryonic stem cell
Asthma
respiratory tract diseases
030104 developmental biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
Asthmatic Airway Remodeling
Immunology
Cancer research
Molecular Medicine
Airway Remodeling
Lung morphogenesis
Airway
Subjects
Details
- ISSN :
- 09254439
- Volume :
- 1863
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Biochimica et biophysica acta. Molecular basis of disease
- Accession number :
- edsair.doi.dedup.....9d7d2734ea42775c71a112f4a4f5fc35