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Correlation of neuropsychological and metabolic changes after epilepsy surgery in patients with left mesial temporal lobe epilepsy with hippocampal sclerosis
- Source :
- EJNMMI Research, Vol 8, Iss 1, Pp 1-7 (2018), EJNMMI Research
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- Background Epilepsy surgery often causes changes in cognition and cerebral glucose metabolism. Our aim was to explore relationships between pre- and postoperative cerebral metabolism as measured with 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) and neuropsychological test scores in patients with left mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS), who were rendered seizure-free after epilepsy surgery. Results Thirteen patients were included. All had neuropsychological testing and an interictal FDG-PET scan of the brain pre- and postoperative. Correlations between changes in neuropsychological test scores and metabolism were examined using statistical parametric mapping (SPM). There were no significant changes in the neuropsychological test scores pre- and postoperatively at the group level. Decreased metabolism was observed in the left mesial temporal regions and occipital lobe. Increased metabolism was observed in the bi-frontal and right parietal lobes, temporal lobes, occipital lobes, thalamus, cerebellum, and vermis. In these regions, we did not find a correlation between changes in metabolism and neuropsychological test scores. A significant negative correlation, however, was found between metabolic changes in the precuneus and Boston Naming Test (BNT) scores. Conclusions There are significant metabolic decreases in the left mesial temporal regions and increases in the bi-frontal lobes; right parietal, temporal, and occipital lobes; right thalamus; cerebellum; and vermis in patients with left MTLE-HS who were rendered seizure-free after epilepsy surgery. We could not confirm that these changes translate into significant cognitive changes. A significant negative correlation was found between changes in confrontation naming and changes in metabolism in the precuneus. We speculate that the precuneus may play a compensatory role in patients with postoperative naming difficulties after left TLE surgery. Understanding of these neural mechanisms may aid in designing cognitive rehabilitation strategies. Electronic supplementary material The online version of this article (10.1186/s13550-018-0385-5) contains supplementary material, which is available to authorized users.
- Subjects :
- lcsh:Medical physics. Medical radiology. Nuclear medicine
medicine.medical_specialty
lcsh:R895-920
Precuneus
Audiology
Statistical parametric mapping
030218 nuclear medicine & medical imaging
surgery
03 medical and health sciences
0302 clinical medicine
left mesial tempora lobe epilepsie
metabolic changes
Medicine
Radiology, Nuclear Medicine and imaging
Ictal
Epilepsy surgery
Neuropsychological test scores
Original Research
Medicine(all)
FDG-PET metabolism
Hippocampal sclerosis
medicine.diagnostic_test
business.industry
Neuropsychological test
neuropsychological
medicine.disease
Correlation
Boston Naming Test
medicine.anatomical_structure
Radiology Nuclear Medicine and imaging
hippocampal sclerosis
epilepsy
sense organs
business
Occipital lobe
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 2191219X
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- EJNMMI Research
- Accession number :
- edsair.doi.dedup.....9d7be2f992ffbd15cb497edde4365b46