Oncolytic poliovirus directs tumor antigen presentation and T cell activation in vitro

Authors :: Smita K. Nair
Eda K. Holl
Darell D. Bigner
Matthias Gromeier
Ross W. Walton
Michael C. Brown
David Boczkowski
Source :: Journal for Immunotherapy of Cancer
Publisher :: Springer Nature
Abstract: Meeting abstracts Our group has developed an oncolytic poliovirus, PVSRIPO, capable of lysing malignant cells while generating inflammation at the site of the tumor. PVSRIPO is a recombinant polio:rhinovirus chimera, engineered to eliminate neuropathogenicity, that has cancer tropism due to ectopic

Full Text Access

Tools