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Aminobicyclo[2.2.1.]heptane dicarboxylic acids (ABHD), rigid analogs of ACPD and glutamic acid: synthesis and pharmacological activity on metabotropic receptors mGluR1 and mGluR2
- Source :
- Bioorganic & Medicinal Chemistry. 6:195-208
- Publication Year :
- 1998
- Publisher :
- Elsevier BV, 1998.
-
Abstract
- Isomeric norbornane-derived rigid analogs mimicking different potential conformations of ACPD (1-aminocyclopentane-1,3-dicarboxylic acid) and glutamic acid have been synthesized, via the hydantoin route, to be used as conformational probes for bioactive conformations at the glutamatergic receptors of the central nervous system. Activities on metabotropic receptors mGluR1 and mGluR2 are reported and discussed.
- Subjects :
- Stereochemistry
Clinical Biochemistry
Molecular Conformation
Glutamic Acid
Pharmaceutical Science
Hydantoin
Receptors, Metabotropic Glutamate
Biochemistry
Gas Chromatography-Mass Spectrometry
chemistry.chemical_compound
Glutamatergic
Isomerism
Drug Discovery
Cycloleucine
Dicarboxylic Acids
Receptor
Molecular Biology
Chromatography, High Pressure Liquid
Organic Chemistry
Glutamic acid
Norbornanes
Metabotropic receptor
Models, Chemical
chemistry
Molecular Medicine
ACPD
Metabotropic glutamate receptor 1
Metabotropic glutamate receptor 2
Subjects
Details
- ISSN :
- 09680896
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry
- Accession number :
- edsair.doi.dedup.....9d6aa750fc6c492299d459409817854d