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Impaired ovarian stimulation during in vitro fertilization in women who are seropositive for hepatitis C virus and seronegative for human immunodeficiency virus
- Source :
- Fertility and sterility. 88(3)
- Publication Year :
- 2006
-
Abstract
- Objective To analyze the impact of seropositivity with hepatitis C virus (HCV) on in vitro fertilization (IVF) outcomes. Design Retrospective, case-controlled study. Setting Fertility clinic of academic hospital. Patient(s) 42 IVF/intracytoplasmic sperm injection cycles in HCV-seropositive women and 84 matched control cycles. Intervention(s) IVF/intracytoplasmic sperm injection treatment for infertility. Main Outcome Measure(s) Ovarian response to stimulation, laboratory findings, and implantation and pregnancy rates. Result(s) Absence of ovarian response was statistically significantly higher for HCV-seropositive women compared with controls (10/42 vs 5/84 cycles, respectively). For cycles with oocyte retrieval, HCV-seropositive women required more gonadotropin units compared with controls. The maximum estradiol levels and number of collected oocytes were similar, but HCV-seropositive women had statistically significantly fewer embryos available compared with controls. Embryo morphologic features, number of transferred embryos, and rates of implantation and pregnancy were similar for HCV-seropositive women and controls. Conclusion(s) When compared with matched uninfected controls, HCV-seropositive women display a decreased ovarian response.
- Subjects :
- Infertility
Adult
medicine.medical_specialty
medicine.drug_class
media_common.quotation_subject
medicine.medical_treatment
Hepatitis C virus
Fertility
Fertilization in Vitro
Hepacivirus
Biology
medicine.disease_cause
Intracytoplasmic sperm injection
Andrology
Ovulation Induction
Pregnancy
Internal medicine
HIV Seronegativity
medicine
Humans
Sperm Injections, Intracytoplasmic
media_common
Retrospective Studies
In vitro fertilisation
Case-control study
Pregnancy Outcome
Obstetrics and Gynecology
medicine.disease
Endocrinology
Reproductive Medicine
Case-Control Studies
Female
Gonadotropin
Subjects
Details
- ISSN :
- 15565653
- Volume :
- 88
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Fertility and sterility
- Accession number :
- edsair.doi.dedup.....9d6512e4453a4d908c429ac77e4b6e40