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Ultra‐Conformable Ionic Skin with Multi‐Modal Sensing, Broad‐Spectrum Antimicrobial and Regenerative Capabilities for Smart and Expedited Wound Care
- Source :
- Advanced Science, Vol 8, Iss 9, Pp n/a-n/a (2021), Advanced Science
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- While rapid wound healing is essential yet challenging, there is also an unmet need for functional restoration of sensation. Inspired by natural skin, an ultra‐conformable, adhesive multi‐functional ionic skin (MiS) with multi‐modal sensing capability is devised for smart and expedited wound care. The base of MiS is a unique skin‐like, conductive and self‐adaptive adhesive polyacrylamide/starch double‐network hydrogel (PSH) and self‐powered, flexible, triboelectric sensor(s) is integrated on top of PSH for multi‐tactile sensing. MiS could enhance wound contraction, collagen deposition, angiogenesis, and epidermis formation in a full‐thickness skin defect wound model in vivo, while significantly inhibiting the biofilm formation of a wide range of microorganisms. MiS also exhibits multi‐modal sensing capability for smart and instant therapeutics and diagnostics, including skin displacement or joint motion, temperature, pressure and tissue exudate changes of wound bed, and locally releasing drugs in a pH‐responsive manner. More importantly, MiS could restore the skin‐mimicking tactile sensing function of both touch location and intensity, and thus could be used as a human‐machine interface for accurate external robotic control. MiS demonstrates a new comprehensive paradigm of combining wound diagnosis and healing, broad‐spectrum anti‐microbial capability and restoration of multi‐tactile sensing for the reparation of severe wound.<br />An ultra‐conformable, adhesive multi‐functional ionic skin (MiS) with multi‐modal sensing capability is devised for smart and expedited wound care. MiS is composed of a polyacrylamide/starch double‐network hydrogel and a self‐powered, flexible, triboelectric sensor. MiS demonstrates a comprehensive paradigm of combining wound diagnosis and healing, broad‐spectrum anti‐microbial capability and restoration of multi‐tactile sensing for advanced wound management.
- Subjects :
- Materials science
smart wound care
Swine
General Chemical Engineering
Science
General Physics and Astronomy
Medicine (miscellaneous)
Biocompatible Materials
02 engineering and technology
In Vitro Techniques
010402 general chemistry
01 natural sciences
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Unmet needs
Mice
Wound care
Broad spectrum
Biomimetics
Animals
Humans
General Materials Science
ionic skin
Research Articles
Skin, Artificial
Wound Healing
Robotic control
gel‐point adhesive hydrogel (GPAH)
Tissue Scaffolds
integumentary system
General Engineering
Adhesiveness
Hydrogels
Robotics
Conformable matrix
021001 nanoscience & nanotechnology
tactile sensing
Anti-Bacterial Agents
0104 chemical sciences
Touch
Biofilms
Models, Animal
antimicrobial
0210 nano-technology
Wound healing
Research Article
Biomedical engineering
Subjects
Details
- Language :
- English
- ISSN :
- 21983844
- Volume :
- 8
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Advanced Science
- Accession number :
- edsair.doi.dedup.....9d62e5e4176a454341e3dd193a8917eb