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RND efflux pumps: structural information translated into function and inhibition mechanisms
- Source :
- ResearcherID
- Publication Year :
- 2013
-
Abstract
- Efflux pumps of the Resistance Nodulation Division (RND) superfamily play a major role in the intrinsic and acquired resistance of Gram-negative pathogens to antibiotics. Moreover, they are largely responsible for multi-drug resistance (MDR) phenomena in these bacteria. The last decade has seen a sharp increase in the number of experimental and computational studies aimed at understanding their functional mechanisms. Most of these studies focused on the RND drug/proton antiporter AcrB, part of the AcrAB-TolC efflux pump actively recognizing and expelling noxious agents from the interior of bacteria. These studies have been focused on the dynamical interactions between AcrB and its substrates and inhibitors, on the details of the proton translocation mechanisms, and on the way AcrB assembles with protein partners to build up a functional pump. In this review we summarize these advances focusing on the role of AcrB.
- Subjects :
- Proton translocation
Models, Molecular
Protein Conformation
Antiporter
Escherichia coli Proteins
Lipoproteins
Cell Membrane
Membrane Transport Proteins
SUPERFAMILY
General Medicine
Drug resistance
Biology
Cell biology
Anti-Bacterial Agents
Antibiotic resistance
Protein structure
Biochemistry
Bacterial Proteins
Drug Resistance, Multiple, Bacterial
Drug Discovery
Gram-Negative Bacteria
Efflux
Multidrug Resistance-Associated Proteins
Function (biology)
Bacterial Outer Membrane Proteins
Subjects
Details
- Language :
- English
- Volume :
- 13
- Issue :
- No. 24
- Database :
- OpenAIRE
- Journal :
- Curr Top Med Chem
- Accession number :
- edsair.doi.dedup.....9d5b26732945b6773a501d0bf12676e0